Fig. 6
From: Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
The pre-application time of SiNP has no significant effect on the magnitude of inhibition of TRPV4 response to GSK1016790A. a Effects of the TRPV4 agonist GSK1016790A on the [Ca2+]i of HEK293T cells transfected with mouse TRPV4. b, c, d TRPV4 responses to GSK1016790A after pre-application of SiNPs during different periods (0, 3 and 10 min for panels b, c and d, respectively). The thick continuous traces correspond to the average responses and the thin dashed traces correspond to the mean plus/minus the standard errors. The black and grey traces correspond to cells with high or low basal [Ca2+]i, respectively (see text). e, f Average amplitude of responses to 2 min applications of GSK1016790A in control and after pre-application of SiNPs for different periods (n = 105 - 385)