Table 1 Effect of nanomaterials on development of allergic airway disease in vivo

C

14

300

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

↑

↑

↑

-

↑

↑

↑ (IL5, IL13, MCP1, IL6); nc (IL4)

↑ Goblet cells

[37]

C

56

45

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

nc

nc

nc

-

nc

↑

↑ (IL5, IL4, IL6, MCP1); nc (IL13)

nc Goblet cells

[37]

C

14

300

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

-

-

-

-

-

-

↑ (MIP1α, IL2, IL10, TARC)

-

[38]

C

56

45

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

-

-

-

-

-

-

↑ (MIP1α, TARC), nc (IL2, IL10)

-

[38]

C

14

300

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

↑ (Resist)

-

-

-

-

-

-

-

nc MUC5AC

[40]

C

56

45

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

↑ (Resist)

-

-

-

-

-

-

-

↑ MUC5AC

[40]

C

14

-

887

Mice (BALB/c –f)

OVA (PA)

PA

2.5 mg/kg x4

-

↑

↑

↑

-

nc

↑

↑ (CXCL1, IL13), nc (IL4)

-

[41]

C

30-50

-

-

Mice (BALB/c –f)

OVA (IP)

Int N

11 mg/kg

-

↑

↑

nc

nc

nc

↑

↑ TNFα, IL4, IL5, IL10, INFγ

↑ PAS

[42]

C

14.3

253.9

-

Mice (BALB/c –f)

OVA (Int N)

Int N

3.6 mg/kg x3

-

nc

↑

↑

nc

nc

↑

↑ (IL4, IL5, IL10, IL13, INFγ, TNFα)

-

[43]

C

30-50

-

-

Mice (BALB/c –f)

OVA (Int N)

Int N

3.6 mg/kg x3

-

-

-

-

-

nc

-

↑ (IL-4, IL-5, IL-10, IL-13, IFN-γ, TNFα)

-

[72]

C

14

300

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

-

-

-

-

↑

↑

↑ (CD86, CD80, MHC II, DEC205, CD19)

-

[39]

C

56

45

-

Mice (ICR –m)

OVA (Int T)

Int T

1.61 mg/kg x6

-

-

-

-

-

nc

nc

nc (CD86, CD80, MHC II, DEC205, CD19)

-

[39]

C

13

-

<10 μm

Rat (BN –m)

OVA (IP)

Int T

0.5 mg/kg x3

nc (Resist)

nc

↓

nc

↑

nc

nc

nc (INFγ, IL1β, TNFα, IL4, IL5, IL13)

-

[238]

TiO₂

29

49.8

-

Mice (BALB/c –f)

OVA (Int N)

Int N

11 mg/kg

-

↑

nc

nc

nc

nc

↑

↑ (TNFα, IL4, IL5, IL10, IL13) nc(INF-γ)

-

[43]

C₇₀ Fullerene

-

-

-

Mice (BALB/c)

OVA (IP)

Int N

1.1 mg/kg

↓ (Resist)

↓

↓

nc

-

nc

↓

↓ (IL4, IL5), ↑ (CYP1B1)

-

[106]

Fe₂O₃

35

39

-

Mice (BALB/c –f)

OVA (IP)

Int T

27.7 mg/kg x4

-

↓

↓

nc

↓

-

-

↓ IL4, INFγ

-

[80]

GO

D 0.6 L 0.02-2μm

-

-

Mice (BALB/c –f)

OVA (IP)

PA

2.2 mg/kg

↑ (Penh)

↓

↓

nc

nc

↑

-

↓ (IL4, IL13) nc (IL5)

↑ GCH/PAS

[65]

Latex

25

-

-

Mice (ICR –m)

OVA (Int T)

Int T

13.8 mg/kg

-

nc

nc

↑

↑

↑

↑

↑ (IL18, MIP1α, MCP1); nc (IL5, IL13)

-

[272]

Latex

50

-

-

Mice (ICR –m)

OVA (Int T)

Int T

13.8 mg/kg

-

nc

nc

↑

↑

↑

↑

↑ (IL18, MIP1α, MCP1); nc (IL5, IL13)

-

[272]

Latex

100

-

-

Mice (ICR –m)

OVA (Int T)

Int T

13.8 mg/kg

-

nc

nc

nc

nc

nc

nc

↑ (IL18, MIP1α, MCP1); nc (IL5, IL13)

-

[272]

PS (Glycine)

50

-

-

Mice (BALB/c –f)

OVA (IP)

Int T

11 mg/kg

-

-

↓

nc

↓

nc

↓

↓ (IL5, IL13)

-

[79]

PS

59

-

-

Mice (BALB/c –f)

OVA (Int N)

Int N

16 mg/kg x3

-

↑

↑

↑

↑

↑

↑

-

-

[44]

PS

59

-

-

Mice (BALB/c –m)

OVA (Int N)

Int N

16 mg/kg x3

-

↑

↑

↑

↑

↑

↑

-

-

[44]

PS (Glycine)

45-49

-

-

Mice (BALB/c)

OVA (Int T)

Int T

11 mg/kg x2

nc

↓

↓

nc

nc

nc

↓

↓ (IL-4, IL-5, IL-13), nc (IFN-γ)

↓ PAS

[78]

SiO₂

7

300

-

Mice (C57BL/6-f)

OVA (Inh)

PA

2.7 mg/kg

-

nc

-

-

-

-

-

↑(HO1); nc(TNFα,,IL1β, Cxcl2, Ccl2)

-

[55]

SiO₂

34

80

-

Mice (C57BL/6-f)

OVA (Inh)

PA

2.7 mg/kg

-

nc

-

-

-

-

-

↑(HO1); nc(TNFα,,IL1β, Cxcl2, Ccl2)

-

[55]

TiO₂ (Al(OH)₃)

30-50

37.1

-

Mice (C57BL/6-f)

OVA (Inh)

PA

2.7 mg/kg

-

nc

-

-

-

-

-

nc (HO1, TNFα, IL1β, Cxcl2, Ccl2)

-

[55]

ZnO

21

49.6

-

Mice (C57BL/6-f)

OVA (Inh)

PA

2.7 mg/kg

-

↑

-

-

-

-

-

nc (HO1, TNFα, IL1β, Cxcl2, Ccl2)

-

[55]

ZnO (SiO₂)

25

-

-

Mice (C57BL/6-f)

OVA (Inh)

PA

2.7 mg/kg

-

↑

-

-

-

-

-

-

-

[55]

SiO₂

10-20

140-180

-

Rat (Wistar –m)

OVA (IP)

Int T

1.6 mg/kg x30

↑ (Resist)

-

↓

-

-

-

-

↑ (IL-4), nc (INF-γ)

-

[46]

SiO₂ (PEG)

90

-

-

Mice (BALB/c –f)

OVA (Int N)

Int N

22.2 mg/Kg x4

-

↑

↑

↑

↑

nc

↑

↑ (IL-6, IL-5, IL-1β, IL-4, TNF-α, INF-γ

↑ PAS, MUC5AC

[47]

SiO₂

100

12.7

119.6

Mice (BALB/c –f)

OVA (Int N)

Int N

10 mg/kg x6

↑ (Resist)

-

↑

↑

↑

nc

↑

↑ (IL-5, IL-13, IL-1β, INF-γ

nc PAS

[48]

SiO₂ (Meso)

100

70.6

100.5

Mice (BALB/c –f)

OVA (Int N)

Int N

10 mg/kg x6

↑ (Resist)

-

↑

↑

↑

↑

↑

↑ (IL-1β, INF-γ) nc (IL-5, IL-13)

↑ PAS

[48]

SiO₂ (PEG)

100

12.7

439.1

Mice (BALB/c –f)

OVA (Int N)

Int N

10 mg/kg x6

nc (Resist)

-

nc

nc

nc

nc

nc

↑ (INF-γ) nc (IL-1β, IL-5, IL-13)

nc PAS

[48]

TiO₂

21

-

1.5 μm

Mice (BALB/c –f)

OVA (IP)

A (Nose only)

193μg, deposited

nc (resist)

↓

↓

nc

↓

nc

↓

↓ (IL-5, IL-6, INF-γ, IL-13, IL-4)

-

[120]

TiO₂ (SiO₂)

10x40

132

100

Mice (BALB/c –f)

OVA (IP)

A

10mg/m³ 2h/d x12d

↓ (Penh)

nc

↓

nc

↓

↓

-

↓ (IL-1β, TNF-α, IL-4, IL-13, IL-10)

↓ PAS

[81]

TiO₂

4-8

130

244

Mice (BALB/c)

OVA (IP)

Int N

11 mg/kg

↑ (Resist)

↑

-

-

-

-

-

nc (IL-5) ↑ (IL-4, IL-13,IL-6, TNFa)

-

[273]

ZnO

50

10.8

-

Mice (Balb/c –f)

OVA (OA)

OA

0.5 mg/kg x2

-

nc

↑

-

-

-

↑

↑ (IL-4, IL-5, IL-6, IL-13)

-

[56]

CNF

D-35, L-10μm

103

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

nc

nc

nc

nc

nc

nc (MCP-1, TNF-α)

-

[54]

CNF

D- 36, L-5μm

124

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

nc

↑

nc

↑

↑

nc (MCP-1, TNF-α)

-

[54]

CNF

D-70, L-5μm

56

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

nc

nc

nc

nc

nc

nc (MCP-1, TNF-α)

-

[54]

CNF

D- 83, L-10μm

61

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

nc

↑

nc

nc

↑

nc (MCP-1, TNF-α)

-

[54]

SWCNT

D- 1.1, L-100μm

543

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

↑

↑

↑

↑

↑

nc (MCP-1, TNF-α)

-

[54]

MWCNT

D20-30, L-200μm

140

-

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

↑

↑

nc

↑

↑

nc (MCP-1, TNF-α)

-

[54]

C (PrinteX 90)

14

300

Mice (BALB/c –f)

OVA (IP)

Int N

7.4mg/kg x3

-

↑

↑

↑

↑

↑

↑

↑(MCP-1),

nc (TNF-α)

-

[54]

SWCNT

D 1.2-2, L 1-15μm

-

-

Mice (ICR –m)

OVA (Int T)

Int T

1.3 mg/kg x7

-

↑

↑

↑

↑

↑

↑

↑ (IL4, IL33, IL5, IL13, INFγ, IL17)

↑ MUC5AC

[52]

SWCNT

D 0.8-1.2, L 0.1-1μm

-

-

Mice (ICR –m)

OVA (Int T)

Int T

1.3 mg/kg x7

-

↑

↑

↑

↑

nc

↑

↑ (IL5, IL13)

↑ MUC5AC

[52]

MWCNT

D ~15 nm, L 1-10μm

-

-

Mice (BALB/c –m)

OVA (Int N)

Int N

1mg/kg

↑ (sRaw)

↑

↑

↑

↑

↑

↑

↑ (IL-4, IL-5, IL-13, IL-17)

-

[50]

SWCNT

D 0.93-1.63

-

-

Rat (Wistar –m)

OVA (Int T)

Int T

2 mg/kg x13

↑ (Resist)

↑

↑

↑

↑

-

↑

↑ (IL4, ROS) ↓(INFγ)

↑ PAS

[53]

MWCNT

D ~15 nm, L 1-10μm

-

~350 μm

Mice (BALB/c –m)

HDM (Int N)

Int N

12.5mg/kg x10

-

-

↑

↑

↑

↑

↑

↑ IL-13, TGF-β1, IL-33, TSLP, IL-25

↑ mucin

[51]

MWCNT

D 67, L 0.1-10μm

26

-

Mice (ICR –m)

OVA (Int I)

Int T

4.6 mg/kg x6

-

↑

↑

↑

↑

nc

↑

↑ (IL-4, INF-γ, IL-33, IL-1β, TARC, MCP-1)

↑ PAS

[49]

MWCNT

D 2–20, L 0.1-10μm

-

-

Mice (ICR –m)

OVA (Int I)

Int T

4.6 mg/kg x6

-

↑

↑

↑

↑

nc

↑

↑ (IL-4, INF-γ, IL-33, MCP-1, IL-1β);

-

[49]

SiO₂

33

-

-

Mice (BALB/c –f)

OVA (Int N)

Int N

13.8 mg/kg x3

-

↑

-

-

-

-

-

↑ (IL-4, IL-5)

-

[45]

SiO₂

79

-

-

Mice (BALB/c –f)

OVA (Int N)

Int N

13.8 mg/kg x3

-

nc

-

-

-

-

-

nc (IL-4, IL-5)

-

[45]