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Table 4 Summary studies of in vivo exposures and focussed investigation of engineered nanomaterial characteristics

From: Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease

Material Type Models of Asthma and Allergic Airway Disease Nanomaterial Characteristics Specifically Investigated for Effects in Models of Asthma and Allergic Airway Disease
Allergen Exposure Models of AAD Pulmonary Exposure Primary Size Solubility Shape/Structure Agg size Charge Composition Surface Area Surface Chemistry/Coating
ALLERGEN INDEP SENSITISATION EXACERBATION
CNPs [41] [40] [60] [37] [38] [59] [58] [62] [238] [37] [38] [39] [40] [41] [42] [43] [54] [72] [238] [58] [59, 60] [61, 62] [110] [127] [277] [37] [38] [39] [40] [42] [54] [40] [37] [38]   [54]    [43] [127] [54]  
MWCNT [169] [134] [135] [50] [278] [67] [69] [70] [51] [49] [49] [50, 51] [54] [67] [68] [69] [70] [71] [147] [49] [54]   [49] [54] [134]     [54]  
SWCNT [136] [52] [52, 53] [54]    [54] [52]   [54] [52]     [54]  
CNF   [54]    [54]   [54]     [54]  
AgNP [132] [111] [116]   [111] [112] [116] [274]   [132]     [132]    [132]
AuNP    [63] [117]        [63]   
Co3O4NP     [126] [127] [279]       [126] [127] [279]   
CuONP [64] [64]   [64] [279] [280]   [280]     [279] [280]   
NiONP     [126] [127] [279] [280] [281] [282] [146]   [280] [281]     [126] [127] [279] [280]   
TiO2NP [119] [133] [81] [119] [43] [55] [120] [81] [273] [63] [120] [118] [119] [273] [126] [127] [283]   [55]     [43] [55] [63] [126] [127]   
CeO2NP     [104]         
ZnONP [56] [56] [55] [56]   [280] [194]   [55] [56] [280] [194]     [55] [280]   [55]
Fullerene   [106]           
FeNP [275] [80] [80] [275] [93]          
GONP [65] [65] [65]          
Latex NP [272] [272]    [272] [272]        
PSPNP [79] [44] [79]    [44]        
SiO2NP [48] [46] [47] [276] [48] [45] [46, 47] [48] [55] [66] [276]   [45] [55] [55]   [48] [66] [55] [48] [55] [276] [48] [66] [276]
TOTALS 42 30 27 12 17 5 4 1 2 7 4 5
  1. Abbreviations: Agg agglomerate, GO Graphene Oxide, MWCNT multi-walled carbon nanotubes, SWCNT Single-walled carbon nanotubes, CNF Carbon Nanofibres