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Table 4 Percentage of NiO burden in each organ per administered dose. Values for the (A) lung, (B) bronchoalveolar lavage fluid (BALF), (C) trachea, and (D) lymph nodes are shown

From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats

(A) Lung
  Percentage of lung NiO burden per administered dose
3 days after i.t. 28 days after i.t. 91 days after i.t.
NiO A 0·57 mg/kg-bw 53% ± 11% 56% ± 8.7% 46% ± 5.3%
1·9 mg/kg-bw 44% ± 21% 66% ± 8.0% 62% ± 4.8%
5·8 mg/kg-bw 67% ± 17% 71% ± 3.0% 60% ± 14%
NiO B 0·45 mg/kg-bw 33% ± 1.6% 0.87% ± 0.051% 0.28% ± 0.032%
1·5 mg/kg-bw 22% ± 1.5% 0.48% ± 0.10% 0.12% ± 0.020%
4·0 mg/kg-bw 22% ± 2.1% 0.50% ± 0.12% 0.088% ± 0.049%
NiO C 0·47 mg/kg-bw 4.8% ± 1.3% 3.4% ± 1.9% 1.7% ± 0.22%
2·0 mg/kg-bw 18% ± 5.5% 19% ± 9.3% 13% ± 4.5%
5·8 mg/kg-bw 39% ± 10% 41% ± 14% 42% ± 19%
NiO D 0·50 mg/kg-bw 100% ± 6.3% 64% ± 12% 51% ± 3.8%
1·6 mg/kg-bw 100% ± 11% 62% ± 16% 54% ± 4.0%
5·0 mg/kg-bw 90% ± 16% 61% ± 16% 40% ± 7.9%
(B) Bronchoalveolar lavage fluid (BALF)
  Percentage of BALF NiO burden per administered dose
3 days after i.t. 28 days after i.t. 91 days after i.t.
NiO A 0·57 mg/kg-bw 1.2% ± 0.31% 0.51% ± 0.13% 0.59% ± 0.17%
1·9 mg/kg-bw 0.28% ± 0.17% 0.61% ± 0.068% 0.39% ± 0.034%
5·8 mg/kg-bw 0.51% ± 0.37% 1.9% ± 0.62% 0.57% ± 0.42%
NiO B 0·45 mg/kg-bw 1.1% ± 0.31% 0.35% ± 0.19% 0.15% ± 0.058%
1·5 mg/kg-bw 0.94% ± 0.22% 0.11% ± 0.015% 0.058% ± 0.013%
4·0 mg/kg-bw 0.65% ± 0.19% 0.050% ± 0.015% 0.016% ± 0.0049%
NiO C 0·47 mg/kg-bw 0.078% ± 0.021% 0.11% ± 0.053% 0.088% ± 0.031%
2·0 mg/kg-bw 0.64% ± 0.81% 0.45% ± 0.20% 0.39% ± 0.092%
5·8 mg/kg-bw 0.39% ± 0.098% 0.50% ± 0.42% 0.43% ± 0.34%
NiO D 0·50 mg/kg-bw 2.6% ± 0.39% 2.5% ± 1.1% 1.3% ± 0.13%
1·6 mg/kg-bw 1.8% ± 0.49% 3.9% ± 1.6% 1.8% ± 0.46%
5·0 mg/kg-bw 1.9% ± 0.63% 1.6% ± 0.74% 1.9% ± 0.54%
(C) Trachea
  Trachea NiO burden per initial body weight [mg/kg bw]
3 days after i.t. 28 days after i.t. 91 days after i.t.
NiO A 0·57 mg/kg-bw 0.77% ± 0.25% 0.38% ± 0.12% 0.30% ± 0.085%
1·9 mg/kg-bw 0.33% ± 0.17% 0.19% ± 0.050% 0.20% ± 0.085%
5·8 mg/kg-bw 0.21% ± 0.15% 0.39% ± 0.16% 0.16% ± 0.075%
NiO B 0·45 mg/kg-bw 0.14% ± 0.031% 0.035% ± 0.047% 0.023% ± 0.017%
1·5 mg/kg-bw 0.10% ± 0.028% 0.0052% ± 0.0021% 0.0040% ± 0.00050%
4·0 mg/kg-bw 0.086% ± 0.040% 0.0020% ± 0.00033% 0.0015% ± 0.0011%
NiO C 0·47 mg/kg-bw 0.087% ± 0.030% 0.027% ± 0.013% 0.026% ± 0.0097%
2·0 mg/kg-bw 0.28% ± 0.14% 0.19% ± 0.13% 0.13% ± 0.078%
5·8 mg/kg-bw 0.40% ± 0.19% 0.29% ± 0.097% 0.28% ± 0.079%
NiO D 0·50 mg/kg-bw 0.52% ± 0.084% 0.38% ± 0.065% 0.25% ± 0.12%
1·6 mg/kg-bw 0.46% ± 0.16% 0.30% ± 0.12% 0.15% ± 0.017%
5·0 mg/kg-bw 0.24% ± 0.078% 0.27% ± 0.19% 0.21% ± 0.084%
(D) Lymph nodes
  Lymph nodes NiO burden per initial body weight [mg/kg bw]
3 days after i.t. 28 days after i.t. 91 days after i.t.
NiO A 0·57 mg/kg-bw 0.040% ± 0.019% 0.75% ± 0.30% 1.4% ± 0.32%
1·9 mg/kg-bw 0.068% ± 0.015% 1.6% ± 0.14% 1.7% ± 0.84%
5·8 mg/kg-bw 0.10% ± 0.050% 3.0% ± 0.26% 3.6% ± 1.4%
NiO B 0·45 mg/kg-bw 0.051% ± 0.0053% 0.031% ± 0.0069% 0.017% ± 0.0062%
1·5 mg/kg-bw 0.025% ± 0.0029% 0.014% ± 0.0013% 0.0092% ± 0.0051%
4·0 mg/kg-bw 0.012% ± 0.0018% 0.012% ± 0.0036% 0.0040% ± 0.00083%
NiO C 0·47 mg/kg-bw 0.0088% ± 0.0026% 0.0062% ± 0.0024% 0.0057% ± 0.0022%
2·0 mg/kg-bw 0.015% ± 0.0061% 0.065% ± 0.063% 0.23% ± 0.15%
5·8 mg/kg-bw 0.052% ± 0.023% 0.67% ± 0.31% 2.0% ± 1.1%
NiO D 0·50 mg/kg-bw 0.11% ± 0.0047% 1.7% ± 0.29% 2.2% ± 0.63%
1·6 mg/kg-bw 0.17% ± 0.020% 3.0% ± 1.4% 4.0% ± 0.69%
5·0 mg/kg-bw 0.15% ± 0.018% 5.2% ± 2.2% 11% ± 2.4%