Table 4 Percentage of NiO burden in each organ per administered dose. Values for the (A) lung, (B) bronchoalveolar lavage fluid (BALF), (C) trachea, and (D) lymph nodes are shown

3 days after i.t.

28 days after i.t.

91 days after i.t.

NiO A

0·57 mg/kg-bw

53% ± 11%

56% ± 8.7%

46% ± 5.3%

1·9 mg/kg-bw

44% ± 21%

66% ± 8.0%

62% ± 4.8%

5·8 mg/kg-bw

67% ± 17%

71% ± 3.0%

60% ± 14%

NiO B

0·45 mg/kg-bw

33% ± 1.6%

0.87% ± 0.051%

0.28% ± 0.032%

1·5 mg/kg-bw

22% ± 1.5%

0.48% ± 0.10%

0.12% ± 0.020%

4·0 mg/kg-bw

22% ± 2.1%

0.50% ± 0.12%

0.088% ± 0.049%

NiO C

0·47 mg/kg-bw

4.8% ± 1.3%

3.4% ± 1.9%

1.7% ± 0.22%

2·0 mg/kg-bw

18% ± 5.5%

19% ± 9.3%

13% ± 4.5%

5·8 mg/kg-bw

39% ± 10%

41% ± 14%

42% ± 19%

NiO D

0·50 mg/kg-bw

100% ± 6.3%

64% ± 12%

51% ± 3.8%

1·6 mg/kg-bw

100% ± 11%

62% ± 16%

54% ± 4.0%

5·0 mg/kg-bw

90% ± 16%

61% ± 16%

40% ± 7.9%

3 days after i.t.

28 days after i.t.

91 days after i.t.

NiO A

0·57 mg/kg-bw

1.2% ± 0.31%

0.51% ± 0.13%

0.59% ± 0.17%

1·9 mg/kg-bw

0.28% ± 0.17%

0.61% ± 0.068%

0.39% ± 0.034%

5·8 mg/kg-bw

0.51% ± 0.37%

1.9% ± 0.62%

0.57% ± 0.42%

NiO B

0·45 mg/kg-bw

1.1% ± 0.31%

0.35% ± 0.19%

0.15% ± 0.058%

1·5 mg/kg-bw

0.94% ± 0.22%

0.11% ± 0.015%

0.058% ± 0.013%

4·0 mg/kg-bw

0.65% ± 0.19%

0.050% ± 0.015%

0.016% ± 0.0049%

NiO C

0·47 mg/kg-bw

0.078% ± 0.021%

0.11% ± 0.053%

0.088% ± 0.031%

2·0 mg/kg-bw

0.64% ± 0.81%

0.45% ± 0.20%

0.39% ± 0.092%

5·8 mg/kg-bw

0.39% ± 0.098%

0.50% ± 0.42%

0.43% ± 0.34%

NiO D

0·50 mg/kg-bw

2.6% ± 0.39%

2.5% ± 1.1%

1.3% ± 0.13%

1·6 mg/kg-bw

1.8% ± 0.49%

3.9% ± 1.6%

1.8% ± 0.46%

5·0 mg/kg-bw

1.9% ± 0.63%

1.6% ± 0.74%

1.9% ± 0.54%

3 days after i.t.

28 days after i.t.

91 days after i.t.

NiO A

0·57 mg/kg-bw

0.77% ± 0.25%

0.38% ± 0.12%

0.30% ± 0.085%

1·9 mg/kg-bw

0.33% ± 0.17%

0.19% ± 0.050%

0.20% ± 0.085%

5·8 mg/kg-bw

0.21% ± 0.15%

0.39% ± 0.16%

0.16% ± 0.075%

NiO B

0·45 mg/kg-bw

0.14% ± 0.031%

0.035% ± 0.047%

0.023% ± 0.017%

1·5 mg/kg-bw

0.10% ± 0.028%

0.0052% ± 0.0021%

0.0040% ± 0.00050%

4·0 mg/kg-bw

0.086% ± 0.040%

0.0020% ± 0.00033%

0.0015% ± 0.0011%

NiO C

0·47 mg/kg-bw

0.087% ± 0.030%

0.027% ± 0.013%

0.026% ± 0.0097%

2·0 mg/kg-bw

0.28% ± 0.14%

0.19% ± 0.13%

0.13% ± 0.078%

5·8 mg/kg-bw

0.40% ± 0.19%

0.29% ± 0.097%

0.28% ± 0.079%

NiO D

0·50 mg/kg-bw

0.52% ± 0.084%

0.38% ± 0.065%

0.25% ± 0.12%

1·6 mg/kg-bw

0.46% ± 0.16%

0.30% ± 0.12%

0.15% ± 0.017%

5·0 mg/kg-bw

0.24% ± 0.078%

0.27% ± 0.19%

0.21% ± 0.084%

3 days after i.t.

28 days after i.t.

91 days after i.t.

NiO A

0·57 mg/kg-bw

0.040% ± 0.019%

0.75% ± 0.30%

1.4% ± 0.32%

1·9 mg/kg-bw

0.068% ± 0.015%

1.6% ± 0.14%

1.7% ± 0.84%

5·8 mg/kg-bw

0.10% ± 0.050%

3.0% ± 0.26%

3.6% ± 1.4%

NiO B

0·45 mg/kg-bw

0.051% ± 0.0053%

0.031% ± 0.0069%

0.017% ± 0.0062%

1·5 mg/kg-bw

0.025% ± 0.0029%

0.014% ± 0.0013%

0.0092% ± 0.0051%

4·0 mg/kg-bw

0.012% ± 0.0018%

0.012% ± 0.0036%

0.0040% ± 0.00083%

NiO C

0·47 mg/kg-bw

0.0088% ± 0.0026%

0.0062% ± 0.0024%

0.0057% ± 0.0022%

2·0 mg/kg-bw

0.015% ± 0.0061%

0.065% ± 0.063%

0.23% ± 0.15%

5·8 mg/kg-bw

0.052% ± 0.023%

0.67% ± 0.31%

2.0% ± 1.1%

NiO D

0·50 mg/kg-bw

0.11% ± 0.0047%

1.7% ± 0.29%

2.2% ± 0.63%

1·6 mg/kg-bw

0.17% ± 0.020%

3.0% ± 1.4%

4.0% ± 0.69%

5·0 mg/kg-bw

0.15% ± 0.018%

5.2% ± 2.2%

11% ± 2.4%