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Table 8 Overview of the direction of observed metabolomic effects in various biochemical pathways following HepG2 exposures to CeO2, CuO and SiO2 particles

From: Metabolomic effects of CeO2, SiO2 and CuO metal oxide nanomaterials on HepG2 cells

Biochemical Pathway Lipids fatty acids monoacyl-glycerols Lipids Phospholipids Sphingolipids Lysolipids Ascorbic acid synthesis Glucuronidation-related Methylation-related Glutathione-related Dipeptides NAD-(P)H system Glycogen Creatinine metabolism Polyamines Nucleotides Nucleic acid degrad-ation products
CeO2 Up Down Down Down Down Down Up Up Up Down Up
CuO Up Up Down Down Up Down Up Up Up Up Up
SiO2 Up Down Down Down Up Up Down
Example biochemical in pathway oleate (18:1n9) choline phosphate gulonic acid UDP-glucuronate S-adenosyl-methionine (SAM) gamma-glutamyl-threonine phenylalanyl-alanine NADPH maltotriose creatinine putrescine Cytidine 5′- monophos-phate (5′-CMP) urate
Data in Table number Tables 3 and 4 Tables 3 and 4 Table 5 Table 5 Table 5 Table 5 Table 6 Table 6 Table 6 Table 7 Table 7 Table 7 Table 7
  1. Key: Up = several increases observed; Down = several decreases observed; − = No obvious pattern observed