Fig. 4

PTPN6 inhibited PDCD4 expression in a STAT3-dependent manner. a Representative images of p-STAT3 in mouse lung tissues. b The STAT3 inhibitor (S3I-201) inhibited activation of STAT3 and expression of PDCD4 in A549 and HBE cells. c The STAT3 inhibitor (S3I-201) did not inhibit expression of PTPN6 in mouse lung tissues (n = 6, ^*** P < 0.001, compared with vehicle control). d The STAT3 inhibitor (S3I-201) inhibited expression of PDCD4 in mouse lung tissues (n = 6, ^*** P < 0.001, compared with vehicle control, ^### P < 0.001, compared with Al₂O₃ NPs-treated vehicle mice). e Representative images of PDCD4 expression in mouse lung tissues f Representative images of emphysema and Lm in mouse lungs (n = 36, ^** P < 0.01, compared with vehicle control, ^*** P < 0.001, compared with vehicle control, ^### P < 0.001, compared with Al₂O₃ NPs-exposed vehicle mice). g Representative images of airway remodeling and thickness of fibrosis layer around airway in mouse lungs (n = 36, ^*** P < 0.001, compared with vehicle control, ^### P < 0.001, compared with Al₂O₃ NPs-exposed vehicle mice)