Fig. 3

Effect of inhalation of lead oxide nanoparticles on lung following 6 weeks exposure. a-d control tissues stained with Hematoxylin-Eosin. e-h exposed tissues stained with Hematoxylin-Eosin. Arrows show alterations in lung tissue as thickened septs with congested capillaries (e), alveolar emphysema (f), full-range perivascular infiltrate (g), hemostase with siderophages (h). Scale bar in panels a-h = 100 μm. i-m lung tissue after treatment in transmission electron microscope. i, i’ nanoparticles in cytoplasmic vesicle of alveolar epithelial cell type I, erythrocyte (ery) present in alveolar space. j, j’ nanoparticles in vesicle of alveolar epithelial cell type I. k, k’ nanoparticle beneath edematous changed alveolar epithelial cell type I (epi), neighboring alveolar epithelial cell type I (ep) is intact. l microthrombus in lung venule, accumulation of thrombocytes (thr) is obvious. m thrombocyte (thr) adhering to endothelial cell (ec). Arrowheads show nanoparticles