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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs

Fig. 8

Effect of inhalation of lead oxide nanoparticles on kidney following 6 weeks exposure. a-f kidney tissues stained with Hematoxylin-Eosin. g-i kidney tissues stained with Green-Trichrome. Arrows indicate mononuclear infiltrations. Scale bar in panels a-i = 100 μm. j-o kidney tissue in transmission electron microscope. j control sample of renal corpuscle, podocyte (po), parietal cell (pc), endothelial cell (ec), thrombocyte (thr) in glomerular capillary. k alteration of filtration barrier (fb) morphology after treatment, body of podocyte (po). l intact tubules - proximal tubules (pt), distal tubule (dt) in kidney cortex of lead treated animal. m nanoparticle freely in epithelial cell cytoplasm of proximal tubule, mitochondrion (mi), basement membrane (bm). n nanoparticles freely in intercalated cell cytoplasm of cortical collecting duct. o nanoparticles freely in parietal cell cytoplasm (pc) of Bowman capsule, next to podocyte (po). Details of nanoparticles in the upper corner of panels m, n, o. Arrowheads show nanoparticles

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