From: Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice
DNA SB in the liver following intratracheal instillation | ||||
 | Control | TiO2 | CeO2 | CB |
 day 1 | 4.1 ± 4.6 | 4.3 ± 1.5 | 3.7 ± 1.4 | 5.6 ± 3.7 |
 day 28 | 3.0 ± 1.4 | 2.9 ± 0.8 | 5.2 ± 5.9 | 9.4 ± 7.2**## |
 day 180 | 3.5 ± 0.8 | 3.4 ± 1.0 | 5.5 ± 2.4 | 12.2 ± 8.7***###†|
DNA SB in the liver following intravenous injection | ||||
 | Control | TiO2 | CeO2 | CB |
 day 1 | 3.1 ± 0.9 | 3.0 ± 1.0 | 3.7 ± 1.1 | 17.9 ± 7.9***###†††|
 day 28 | 5.2 ± 4.0 | 3.6 ± 1.1 | 9.7 ± 4.9 | 16.1 ± 10.2***### |
 day 180 | 3.3 ± 0.7 | 5.8 ± 7.2 | 3.7 ± 2.0 | 22.8 ± 11.1***###†††|
DNA SB in the liver following oral gavage | ||||
 | Control | TiO2 | CeO2 | CB |
 day 1 | 5.5 ± 3.8 | 4.6 ± 3.5 | 7.9 ± 8.6 | 13.9 ± 10.4 |
 day 28 | 3.0 ± 0.6 | 2.8 ± 0.6 | 3.3 ± 0.7 | 2.4 ± 0.6 |
 day 180 | 2.8 ± 0.8 | 3.5 ± 0.9 | 3.8 ± 3.5 | 7.2 ± 6.5 |