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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome

Fig. 6

Sample-to-sample distribution and differential expression analysis for transcriptomic analysis. a Assessment of normalized counts between control vs. control (left) and control vs. maternal nano-TiO2 exposed (right) using a log2 transformed scale. b Measure of raw count matrices and (c) normalized count matrices to determine variance between samples. d The top differentially regulated gene between groups was determined through the normalized counts for each sample. e The MA-plot reveals the differentially expressed genes (red, P ≤ 0.05) in comparison to genes with non-significant change between groups (grey). The top differentially regulated gene is highlighted (blue). Exposed and Exp = maternal nano-TiO2 exposed, Car1 = carbonic anhydrase 1

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