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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome

Fig. 7

Assessment of disease and signaling pathways altered transcriptionally during maternal nano-TiO2 exposure. a Similar to the activation by H3K4me3, transcriptional upregulation of genes associated with increased susceptibility to infection (z-score = 2.02 ± 0.96) was found. b The top canonical pathways (z-score ≥ ±3.45) that are significantly (P ≤ 0.05) impacted transcriptionally, as indicated by the threshold line. The canonical pathways for the RNA sequencing reveal a significant increase in inflammatory and growth signaling. c The top regulator (consistency score = 10.453) determined through pathway analysis of gene expression (arrows = activation, bars = repression). Increasing gene activation (red) and suppression (blue) reveal targeting of multiple cell functions. d Toxicological functions predicted for transcript abundance in the RNA sequencing experiment

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