Fig. 8
From: Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome
Comparison of epigenetic regulation (H3K4me3 and H3K27me3) and transcriptional changes. a Top canonical pathways, ranked by z-score, which are changed between groups. b Top toxicological functions, ranked by z-score, which are changed between groups. c Top diseases and biological functions, ranked by z-score, which are changed between groups. d Top canonical pathways, ranked by cumulative P-value, which are changed between groups. e Example of one of the top canonical pathways altered during maternal nano-TiO2 exposure. NF-ĸB signaling changes transcriptionally (right) and epigenetically through H3K4me3 (left) (green = decreased expression, red = increased expression). NF-ĸB = nuclear factor kappa-light-chain-enhancer of activated B cells