Skip to main content

Table 3 Log EC50 and Emax values of concentration-response curves in näive aorta rings from wild-type rats

From: Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

  Concentration (μg/ml) Log EC50 (M) Emax (%)
ACh NTG 5-HT ACh NTG 5-HT
Control 0 −6.1 (− 6.3 to − 5.8) − 6.6 (− 7.0 to − 5.7) − 5.3 (− 5.5 to − 5.2) 42.9 (38.7–48.6) 78.3 (66.7–113.2) 115.8 (105.1–127.5)
E171 14 −5.9 (− 6.1 to − 5.7) − 6.9 (− 7.1 to − 6.6) − 5.4 (− 5.6 to − 5.2) 56.3* (52.5–61.3) 65.3 (59.9–73.5) 148.5* (131.3–168.2)
140 −6.1 (− 6.4 to − 5.6) − 7.1 (− 7.4 to − 6.7) − 5.3 (− 5.5 to − 5.1) 44.9 (38.9–55.2) 67.2 (60.4–79.3) 172.7* (151.4–197.3)
Aeroxide P25 14 −6.1 (− 6.4 to − 5.8) −6.9 (− 7.3 to − 6.1) − 5.3 (− 5.6 to − 5.1) 45.9 (41.8–51.8) 70.8 (61.0–98.8) 130.6 (111.3–152.5)
140 −5.7 (− 6.0 to − 5.3) − 6.8 (− 7.0 to − 6.6) −5.4 (− 5.5 to − 5.3) 42.4 (37.7–51.4) 80.5 (73.7–91.3) 122.5 (114.0–131.4)
E153 10 −6.0 (− 6.2 to − 5.7) −6.8 (− 7.1 to − 6.2) −5.4 (− 5.7 to − 5.1) 50.4 (45.9–57.5) 61.0 (53.3–79.6) 147.0 (122.7–179.5)
100 −5.9 (− 6.1 to − 5.7) − 6.7 (− 7.3 to 0.2) −5.1 (− 5.3 to − 4.9) 57.5* (52.7–64.6) 84.1 (67.5–514.0) 143.4 (125.7–166.5)
Printex 90 10 −6.1 (− 6.7 to − 2.1) −6.0 (− 6.5 to − 3.4) − 5.3 (ND to − 5.2) 48.7 (39.3–161.2) 68.7 (53.0–188.8) 147.1* (134.8–160.0)
100 −6.0 (− 6.3 to − 5.6) −6.4 (− 6.8 to − 5.6) −5.3 (− 5.5 to − 5.2) 50.8 (45.3–59.3) 75.6 (63.9–109.5) 123.6 (112.5–135.4)
  1. The concentration-response curves were performed for acetylcholine (ACh), nitroglycerine (NTG) and 5-hydroxytryptamine (5-HT) on aorta from rats exposed ex vivo to E171, Aeroxide P25, E153 or Printex 90 for 30 min. The data are presented as the mean and 95% CI. The number of animals in each group varied; specified in Figs. 3, 4 and 5. Asterisk (*) denotes statistically significant effects on Emax when compared to the effect in the control group (P < 0.05), ND: the value could not be determined by non-linear regression analysis