Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice

Table 3 Cytokines and chemokines in BALF (pg/ml)

	Con	OVA	OVA/F1(s)	OVA/F1	OVA/F2	OVA/F3	F1
IL-4	0.17 ± 0.06	50.93 ± 22.26^**	149.46 ± 124.91	231.97 ± 154.35^#	56.36 ± 23.12	199.42 ± 110.28^#	0.60 ± 0.31^*
IL-5	N.D.	136.66 ± 57.97	170.42 ± 134.08	253.26 ± 85.01^#	244.68 ± 24.24^#	138.16 ± 94.55	N.D.
IL-13	N.D.	43.05 ± 24.24	46.75 ± 42.45	79.15 ± 22.87^#	71.97 ± 7.28^#	59.11 ± 41.72	N.D.
IL-6	N.D.	8.86 ± 4.11	44.72 ± 37.13^#	62.62 ± 50.37^#	10.93 ± 3.08	53.21 ± 36.97^#	N.D.
IL-10	5.09 ± 3.77	33.70 ± 16.79^*	49.59 ± 47.22	62.09 ± 21.52^#	64.86 ± 20.00^#	64.41 ± 34.99	6.98 ± 5.11
KC	30.81 ± 3.20	148.15 ± 25.71^**	110.13 ± 45.35	151.83 ± 42.91^**	168.54 ± 106.24	113.79 ± 8.59	31.31 ± 7.76
MCP-1	N.D.	10.65 ± 3.90	15.69 ± 11.55	15.25 ± 6.13	13.12 ± 10.10	18.71 ± 11.54	N.D.

Cytokines and chemokines in mouse BALF were investigated using a Millipore mouse cytokine/chemokine magnetic bead panel. Results are expressed as mean ± SEM. n = 5–6 mice/group. ^*p < 0.05 and ^**P < 0.01: OVA or F1 vs. Con; ^#p < 0.05: OVA/ F (refers to F1(s), F1, F2 or F3) vs. OVA; N.D.: non-detected

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