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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)

Fig. 4

Effects of DEP-EOMs on expression of HO-1 and AhR-regulated genes in HMEC-1 cells. Cells were exposed to DEP-EOMs at concentrations corresponding to 5 and 50 μg/mL (0.75 and 7.5 μg/cm2) of native particles, or vehicle (DMSO) alone for 2 and 24 h. The expressions of CYP1A1, CYP1B1, PAI-2 and HO-1 were measured by q-PCR. The mRNA levels are presented relative to gene expression in cells exposed to DMSO, represented by the dotted line at 1. The results are expressed as mean ± SEM (n = 4). *Statistically significant difference from unexposed controls

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