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Table 7 Results of multiple linear regression modeling of complete blood count components

From: Association of pulmonary, cardiovascular, and hematologic metrics with carbon nanotube and nanofiber exposure among U.S. workers: a cross-sectional study

 

CNT/F metric β estimate (p-value)

   

ln(Leukocytes)a

ln(Neutrophils)b

ln(Lymphocytes)c

ln(Monocytes)d

ln(Platelets)e

Hemoglobin2f

Hematocrit2g

Exposure variable – untransformed

 EC–inhalable (μg/m3)

-2.17E-4 (0.692)

-9.34E-5 (0.899)

-3.74E-4 (0.577)

-5.94E-3 (0.364)

2.09E-5 (0.965)

-1.80E-2 (0.775)

-0.237 (0.618)

 EC-respirable (μg/m3)

-3.92E-3 (0.468)

-3.78E-3 (0.533)

-3.32E-3 (0.556)

-4.39E-3 (0.428)

1.59E-3 (0.692)

-0.294 (0.578)

-2.33 (0.563)

 TEM-total (structures/cm3)

-8.30E-2 (0.080)h

-9.06E-2 (0.154)h

-7.51E-2 (0.201)h

-3.03E-2 (0.612)

-3.76E-3 (0.929)

-4.08 (0.463)

-26.9 (0.533)

 CNT/F found in sputum

5.75E-2 (0.380)

8.21E-2 (0.355)

1.90E-2 (0.980)

4.79E-2 (0.542)

-8.40E-2 (0.109)

2.17 (0.332)

32.4 (0.566)

 CNT/F emp. duration (years)

-5.78E-3 (0.316)

-7.34E-2 (0.340)

1.70E-3 (0.814)

3.78E-3 (0.594)

-1.27E-3 (0.804)

0.400 (0.548)

5.28 (0.308)

Exposure variable – log-transformed

 ln(EC-inhalable)

4.05E-3 (0.592)

8.15E-3 (0.419)

-4.31E-3 (0.646)

1.34E-2 (0.149)h

-3.74E-3 (0.575)

1.44 (0.103)

10.3 (0.127)

 ln(EC-respirable)

-1.06E-2 (0.373)

-1.43E-2 (0.371)

-2.40E-3 (0.869)

-9.98E-3 (0.494)

1.30E-2 (0.206)

-0.460 (0.738)

6.02E-3 (0.999)

 ln(TEM-total)

-1.28E-3 (0.885)

6.89E-3 (0.560)

-1.14E-2 (0.303)

-3.20E-3 (0.771)

-1.28E-2 (0.101)h

1.82 (0.0788)h

15.9 (0.0433)h

Effect modification i

 Male

-8.24E-2

-9.31E-2

-7.85E-2

1.45E-2

-6.60E-3

1.85

18.5

 Female

-9.14E-2

-5.31E-2

-2.50E-2

-5.96E-3

-3.59E-2

1.74

7.51

  p for interaction

 0.9596

 0.867

 0.805

 0.531

 0.001

 0.965

 0.553

 White race, non-Hispanic

-8.29E-2

-9.27E-2

-7.52E-2

6.66E-4

-1.23E-2

1.86

14.8

 All other races and Hispanic

-6.23

-6.54

-4.44

1.46E-2

-2.02E-2

1.33

34.0

  p for interaction

 0.009

 0.041

 0.124

 0.646

 0.803

 0.898

 0.542

 Age <40

-9.04E-2

-0.111

-6.72E-2

5.27E-3

-2.19E-2

1.50

16.0

 Age ≥40

1.39E-2

0.178

-2.17E-1

1.76E-2

-8.10E-3

1.95

15.9

  p for interaction

 0.529

 0.191

 0.478

 0.461

 0.067

 0.649

 0.995

 Education < college degree

-8.91E-2

-1.06E-1

-1.18E-1

1.64E-2

-1.64E-2

0.530

4.27

 Education ≥ college degree

-7.65E-2

-7.45E-2

-2.81E-2

1.23E-2

-1.11E-2

2.55

22.7

  p for interaction

 0.890

 0.796

 0.427

 0.836

 0.513

 0.056

 0.020

 No lung diseasej

-8.87E-2

-1.18E-1

-1.19E-2

1.41E-2

-5.11E-3

1.72

14.0

 Has lung disease

-7.96E-2

-6.86E-2

-1.11E-1

1.27E-2

-1.58E-2

1.85

16.5

  p for interaction

 0.924

 0.733

 0.388

 0.934

 0.170

 0.900

 0.747

 CHM score <5

-8.85E-2

-9.98E-2

-8.42E-2

1.45E-2

-2.20E-2

2.25

17.4

 CHM score ≥5

2.86E-2

9.34E-2

6.90E-2

1.28E-2

-8.79E-3

1.42

14.5

  p for interaction

 0.547

 0.458

 0.533

 0.920

 0.085

 0.688

 0.856

  1. Abbreviations—CNT/F carbon nanotubes or nanofibers, CHM cardiovascular health metric, EC elemental carbon, TEM transmission electron microscopy
  2. aLeukocytes adjusted for total U/FP counts per cm3 and self-reported current dust exposure
  3. bNeutrophils adjusted for total U/FP counts per cm3 and self-reported current dust exposure
  4. cLymphocytes adjusted for NSAID use, CHM score, and self-reported past exposure to nanomaterials other than CNT/F
  5. dMonocytes adjusted for race/ethnicity, current respiratory infection, total U/FP counts per cm3 and self-reported past polymer exposure
  6. ePlatelets adjusted for race/ethnicity
  7. fHemoglobin adjusted for sex, race/ethnicity, and CHM score
  8. gHematocrit adjusted for sex, race/ethnicity, CHM score, and current respiratory infection
  9. hCNT/F exposure metric associated with the lowest Schwarz’s Bayesian Criterion value (best fit)
  10. iParameter estimates and p-values are shown for the CNT/F exposure metric identified as having the best fit
  11. jSelf-reported respiratory allergy, asthma, or chronic obstructive pulmonary disease
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Particle and Fibre Toxicology

ISSN: 1743-8977

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