Cytokines | NM105 | NM101 | NM100 | NM212 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose interval | Dose interval | Dose interval | Dose interval | ||||||||||
BMDL | BMDU | Median | BMDL | BMDU | Median | BMDL | BMDU | Median | BMDL | BMDU | Median | ||
In vitro, suspension (24 h) | IL-1β | 0.10 | 11.90 | 4.63–11.20 | 0.53 | 2.85 | 2.82–6.36 | 10.68 | 32.59 | 10.96–26.19 | 0.06 | 10.26 | 0.430–14.168 |
IL-6 | 4.50 | 11.11 | 4.86 | 10.47 | ND | ND | ND | ND | |||||
IL-8 | ND | ND | ND | ND | ND | ND | ND | ND | |||||
TNF-α | 4.76 | 11.20 | 2.82 | 6.36 | 11.25 | 19.80 | 0.80 | 18.08 | |||||
In vitro, suspension (3 h + 21 h) | IL-1β | 0.43 | 2.25 | 0.26–1.51 | 0.60 | 6.61 | 0.80–6.19 | 3.47 | 53.23 | 3.47–55.64 | 3.47 | 54.81 | 3.37–52.50 |
IL-6 | 0.20 | 1.36 | 1.28 | 8.17 | ND | ND | 2.30 | 50.25 | |||||
IL-8 | 0.11 | 1.11 | 0.84 | 3.73 | 3.35 | 58.05 | 3.42 | 9.64 | |||||
TNF-α | 0.31 | 1.66 | 0.76 | 5.78 | 3.83 | 52.87 | 3.31 | 54.75 | |||||
ALI (3 h + 21 h) | IL-1β | 0.051 | 0.80 | 0.061–0.82 | 0.061 | 0.74 | 0.099–0.80 | 0.006 | 0.91 | 0.045–0.90 | 0.63 | 2.61 | 0.88–2.71 |
IL-6 | 0.037 | 0.81 | 0.089 | 0.77 | 0.012 | 0.88 | 0.88 | 2.71 | |||||
IL-8 | 0.078 | 0.83 | 1.13 | 11.87 | 0.078 | 0.90 | ND | ND | |||||
TNF-α | 0.070 | 0.82 | 0.11 | 0.84 | 0.24 | 0.97 | ND | ND | |||||
In vivo | IL-1β | 0.0011 | 0.067 | 0.0007–0.075 | ND | ND | 0.0022–0.084 | ND | ND | ND | ND | ND | 0.0000–0.074 |
IL-6 | 0.00069 | 0.13 | 0.0044 | 0.086 | ND | ND | 0.000 | 0.019 | |||||
IL-8 | 0.00019 | 0.084 | ND | ND | ND | ND | 0.0033 | 0.082 | |||||
TNF-α | 0.00075 | 0.0091 | 0.000 | 0.082 | ND | ND | 0.000 | 0.074 |