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Table 5 LOAELs (μg/106 macrophages for 24 h exposure) determined for pro-inflammatory-effects

From: Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

  1. Significant effects allowing the determination of a LOAEL
  2. No significant adverse effects observed
  3. aDoses tested at the ALI: 1.67, 16.7, 50 μg/106 macrophages
  4. bDoses tested in submerged conditions in inserts: 16.7, 50, 167 μg/106 macrophages
  5. cDoses tested in submerged conditions in plates: 40, 120, 400, 800 μg/106 macrophages
  6. dDoses tested in vivo: 0.16, 1.6, 16 μg/106 macrophages