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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation

Fig. 1

Experimental protocol for intranasal administration of HDM and nanoparticles. Balb/c mice were exposed through intranasal instillation to cerium dioxide nanoparticles (CeO2NPs), low dose (LD) (75 μg/kg) or high dose (HD) (750 μg/kg), alone or in combination with house dust mite (HDM) (1.25 mg protein/kg). Three week exposure protocols involved 9 individual instillations on the indicated days (a). Specific protocols involved either pre-treatment with HDM for the first 8 instillations followed by a combination of HDM + CeO2NPs (SGL) or 9 repeat treatments of CeO2NPs +/− HDM (RPT) as indicated (a). Mice were also exposed to a single instillation of CeO2NPs (LD and HD) +/− HDM (b). Sacrifice and collection of tissues was carried out on the days indicated (a, b)

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