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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study

Fig. 3

Local increases of PI concentration in the rat lung upon SiO2 NP treatment are abrogated by phosphonate coating. Distribution of phosphatidylinositol PI (34:1) 3 d after instillation of SiO2-n, SiO2-p, or SiO2-FITC (0.36 mg/lung): Microscopic images of the investigated cryo-sections (left) and corresponding MALDI-MS ion images of m/z 835.9 (right, detected as [M-H] in negative ion mode) of rat lung treated with a, b vehicle, c, d SiO2-p, e, f SiO2-n, or g, h SiO2-FITC. Note the patchy occurrence of PI upon SiO2-n and SiO2-FITC, but not upon SiO2-p. The seemingly high signal of the vehicle-treated control section results from automated scaling of the relative signal intensity

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