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Table 1 Particle characterization and properties under study conditions (taken from [55])

From: Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study

  SiO2-n SiO2-FITC SiO2-p
Primary particle size (TEM) 5–50 nm 23–30 nm 5–50 nm
Average size (AUC) 19 nm 25 nm 19 nm
Zeta potential, pH 7.4 −39 mV − 39 mV − 42.9 mV
BET surface 200 m2·g− 1 178 m2·g− 1 200 m2·g− 1
Crystallinity (XRD) Amorphous Amorphous Amorphous
Morphology Mostly spherical Mostly spherical Mostly spherical
Surface chemistry in XPS O: 66 at.%
Si: 29 at.%
C: 4 at.%
Na: 1 at.%
O: 63 at.%
Si: 29 at.%
C: 8 at.%
O: 66 at.%
Si: 29 at.%
C: 5 at.%
Na: 0.5 at.%
PO2, PO3: 0.5 at.%
pH of stock suspension 10.2 8.7 10.8
d50 in H2O (NTA) 47.5 ± 0.7 nm n.m. 64.5 ± 10.6 nm
d50 in KRPG buffer (NTA) 65.3 ± 7.5 nm n.m. 60.7 ± 7.8 nm
d50 in F-12 K medium (NTA) 73.3 ± 14 nm n.m. 59.3 ± 8.1 nm
d50 in instillation fluid (NTA) 61.5 ± 7.8 nm 51.0 ± 4.2 nm 50.0 ± 17.0 nm
  1. TEM Transmission electron microscopy, AUC analytical ultracentrifugation, XRD X-ray diffraction, XPS X-ray photoelectron spectroscopy, NTA NanoSight tracking analysis, KRPG Krebs-Ringer phosphate glucose, d50 median diameter, n.m. not measured