Fig. 4

Cytotoxicity and cytostasis. The percentage of apoptotic (a) and necrotic cells (b) as evaluated by annexin V/PI staining (ETO, Etoposide 0.2 μg/mL was used as positive control). The percentage of replication (c) and mitotic (d) indices as evaluated by CBMN Cyt assay (MMC, mitomycin C 0.05 μg/mL was used as positive control). Results are presented as mean ± SEM from three independent experiments (n = 3). *, p < 0.05; **, p < 0.01; ***, p < 0.001