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Table 10 Change in physiological endpoints associated with IQR changes in target biomarkers

From: Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill

Biomarker Physiological Parameters
Change (95% CI)
Systolic BP (mmHg) Diastolic BP (mmHg) Heart Rate (bpm)
Adipsin −1.94 (− 3.62, −0.26)*a 0.38 (− 0.81, 1.04)a − 0.06 (− 1.62, 1.51)a
CRP 0.40 (− 0.28, 1.08)a 0.24 (− 0.27, 0.76)a 1.13 (0.56, 1.69)*b
IL-10 − 0.01 (− 0.85, 0.82)a − 0.15 (− 0.77, 0.47)a − 0.61 (− 1.33, 0.10)+a
IL-12 − 0.07 (− 0.27, 0.14)a − 0.05 (− 0.20, 0.10)a − 0.25 (− 0.42, − 0.08)*a
IL-6 0.08 (− 1.00, 1.15)a − 0.09 (− 0.09, 0.73)a − 1.09 (− 2.01, − 0.17)*a
IL-7 − 0.14 (− 1.05, 0.76)a − 0.20 (− 0.88, 0.47)a − 0.68 (− 1.45, 0.10)+a
PF4 − 1.57 (− 2.95, − 0.19)*a 0.19 (− 0.87, 1.26)a 0.03 (− 1.17, 1.24)a
Plasma BET-1 1.41 (−0.59, 3.41)a − 1.22 (− 2.65, 0.20)*c −0.44 (− 2.17, 1.30)a
Saliva BET-1 1.82 (0.64, 3.00)*a 1.11 (0.08, 2.14)*a − 0.02 (− 1.21, 1.16)a
Saliva ET-1(1–21) 1.78 (−0.25, 3.80)+a 0.66 (− 0.94, 2.25)a − 1.01 (− 2.81, 0.80)a
vWF − 0.35 (− 1.25, 0.55)a 0.77 (0.08, 1.45)*c −0.39 (− 1.22, 0.43)+a
  1. *p < 0.05; +p < 0.1(not significant, trend only)
  2. aCovariates: Treatment period, and carry over
  3. bCovariates:Treatment period, carry over, age, sex and BMI
  4. cCovariates: Treatment period, carry over, age, sex and BMI, atmospheric pressure, temperature, and relative humidity