Table 10 Change in physiological endpoints associated with IQR changes in target biomarkers

Adipsin

−1.94 (− 3.62, −0.26)*^a

− 0.06 (− 1.62, 1.51)^a

CRP

0.40 (− 0.28, 1.08)^a

1.13 (0.56, 1.69)*^b

IL-10

− 0.01 (− 0.85, 0.82)^a

− 0.61 (− 1.33, 0.10)+^a

IL-12

− 0.07 (− 0.27, 0.14)^a

− 0.25 (− 0.42, − 0.08)*^a

IL-6

0.08 (− 1.00, 1.15)^a

− 1.09 (− 2.01, − 0.17)*^a

IL-7

− 0.14 (− 1.05, 0.76)^a

− 0.68 (− 1.45, 0.10)+^a

PF4

− 1.57 (− 2.95, − 0.19)*^a

0.03 (− 1.17, 1.24)^a

Plasma BET-1

1.41 (−0.59, 3.41)^a

−0.44 (− 2.17, 1.30)^a

Saliva BET-1

1.82 (0.64, 3.00)*^a

− 0.02 (− 1.21, 1.16)^a

Saliva ET-1(1–21)

1.78 (−0.25, 3.80)+^a

− 1.01 (− 2.81, 0.80)^a

vWF

− 0.35 (− 1.25, 0.55)^a

−0.39 (− 1.22, 0.43)+^a