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Table 7 Relative change in target biomarker levels associated with IQR changes in air pollutant levels

From: Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill

Pollutant Biomarker Ratio (95%CI)
CO IL-12 1.077 (1.018, 1.139)*
IL-13 1.046 (1.009, 1.086)*
IL-5 1.022 (0.998, 1.047)+
IL-6 1.042 (1.009, 1.077)*
IL-7 1.043 (1.007, 1.080)*
IL-8 1.016 (1.001, 1.032)*
L Selectin 0.966 (0.934, 1.000)*
ET 1–21 (saliva) 0.966 (0.933, 1.000)*
ET 1–31 (saliva) 0.962 (0.920, 1.007)+
ET 3 (saliva) 1.011 (0.975, 1.047)+
NO GMCSF 0.910 (0.818, 1.012)+
IL-4 0.859 (0.718, 1.027)+
IL-8 0.906 (0.845, 0.972)*
NO2 ET 1–21 (saliva) 1.090 (0.904, 1.314)+
NOX IL-8 0.915 (0.847, 0.989)*
O3 Adipsin 0.669 (0.433, 1.034)+
GMCSF 1.170 (0.979, 1.398)+
IL-2 1.476 (1.120, 1.945)*
L Selectin 0.794 (0.630, 1.000)+
Big ET-1 (plasma) 1.417 (1.024, 1.962)*
Big ET-1 (saliva) 0.616 (0.363, 1.046)+
ET 1–21 (saliva) 0.776 (0.609, 0.988)*
SAP 0.672 (0.445, 1.013)+
TNF-α 1.143 (1.006, 1.299)*
vWF 0.562 (0.328, 0.963)*
SO2 Haptoglobin 1.080 (0.988, 1.182)+
PF4 0.914 (0.829, 1.007)+
ET 1–21 (plasma) 1.401 (1.056, 1.858)*
vWF 1.265 (0.953, 1.679)+
UFP A2M 0.543 (0.348, 0.848)*
Adipsin 0.244 (0.095, 0.627)*
AGP 0.362 (0.209, 0.626)*
Fibrinogen 0.504 (0.309, 0.823)*
Haptoglobin 0.548 (0.359, 0.837)*
L Selectin 0.684 (0.495, 0.947)*
PF4 0.464 (0.287, 0.750)*
ET 1–21 (plasma) 4.405 (1.143, 16.973)*
PM2.5 IL-4 0.837 (0.700, 1.000)+
ET 1–21 (saliva) 1.166 (1.001, 1.344)*
ET 1–31 (saliva) 1.195 (0.998, 1.430)+
vWF 1.373 (0.985, 1.912)+
  1. *p < 0.05; +p < 0.1(not significant, trend only)
  2. Covariates: Treatment period, carry over, Age, sex, BMI, atmospheric pressure, temperature and relative humidity