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Table 3 Summary of in vitro T cell differentiation results

From: Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease

In vitro Genotype WT Ahr−/− CypTKO
Dose High Low High Low High Low
Th17 SRM1650b PM   
SRM2975 PM   
Treg SRM1650b PM     
SRM2975 PM     
Th1 SRM1650b PM   
SRM2975 PM   
Th17 SRM1650b OF   
SRM2975 OF   
Treg SRM1650b OF     
SRM2975 OF     
Treg SRM1650b PAHs     
SRM2975 PAHs     
Th17 SRM1650b PAHs
SRM2975 PAHs
  1. Both DEP PM enhanced effector T cell differentiation in an AHR-dependent manner and suppressed regulatory T cell differentiation at high doses. Both DEP OF enhanced effector T cell differentiation in an AHR-dependent manner at high doses and SRM2975 OF suppressed regulatory differentiation at low doses. SRM1650b PAH mixtures enhanced Th17 differentiation at high doses in an AHR-dependent manner and SRM2975 PAH mixtures did not. In the absence of CYP metabolizing enzymes, both diesel PAH mixtures enhanced Th17 differentiation at high doses and SRM2975 maintained this effect at low doses. Symbols: ↑ increase, ↓ decrease, − no change