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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring

Fig. 5

Maternal exposure to Printex 90 carbon nanoparticles dose-dependently increases expression levels of glial fibrillary acidic protein (GFAP) in astrocytes in the offspring hippocampus. a, b, d, e, g and h show representative fluorescent micrographs of GFAP-positive astrocytes in the hippocampi of 6 week old male offspring in the control (a, b), low exposure (d, e), and high exposure group (g, h). a, d and g gives an overview of the hippocampus, with b, e, and h providing enlarged views of panels a, d, and g, respectively. c, f, and i are grayscale views of b, e, and h, respectively, for quantification of GFAP expression. j indicates averages of the expression area of GFAP-positive astrocytes in the hippocampus of offspring based on grayscale views provided in [Additional files 6, 7 and 8], and shows that maternal exposure to the nanoparticles significantly increases expression levels of GFAP of astrocytes in the hippocampus. N is the number of brains analysed, mean ± SEM

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