Table 4 Levels of DNA lesions, 5-mC and 5-hmC in samples from AJ mice exposed to ambient air and to PM2.5 concentrated 30 times
Ambient Air | PM2.5 | Number | P value | |
|---|---|---|---|---|
Average ± SEM | Average ± SEM | |||
Lung | ||||
8-oxodGuo/108 dGuo | 2124 ± 56.96 | 2466 ± 93.10 | 6 | 0.01 |
1,N2-εdGuo/108 dGuo | ND | ND | – | – |
1,N6-εdAdo/108 dAdo | 1.41 ± 0.23 | 1.44 ± 0.13 | 7 | NS |
5-mC (%) | 3.53 ± 0.18 | 3.84 ± 0.21 | 8 | NS |
5-hmC (%) | 0.044 ± 0.006 | 0.029 ± 0.001 | 8 | <0.01 |
Liver | ||||
8-oxodGuo/108 dGuo | 2848 ± 183.5 | 2949 ± 223.8 | 6; 5 | NS |
1,N2-εdGuo/108 dGuo | 7.79 ± 2.49 | 24.94 ± 5.21 | 4 | 0.02 |
1,N6-εdAdo/108 dAdo | 2.82 ± 0.30 | 2.18 ± 0.25 | 6 | NS |
5-mC (%) | 4.68 ± 0.11 | 4.36 ± 0.38 | 8; 6 | NS |
5-hmC (%) | 0.060 ± 0.004 | 0.051 ± 0.002 | 8; 6 | 0.04 |
Kidney | ||||
8-oxodGuo/108 dGuo | 1854 ± 87.13 | 2363 ± 157.0 | 6 | 0.02 |
1,N2-εdGuo/108 dGuo | ND | ND | – | – |
1,N6-εdAdo/108 dAdo | 1.09 ± 0.15 | 1.52 ± 0.12 | 7 | 0.04 |
5-mC (%) | 4.84 ± 0.24 | 4.20 ± 0.37 | 8 | NS |
5-hmC (%) | 0.048 ± 0.003 | 0.048 ± 0.003 | 8 | NS |