Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil

Table 6 Levels of 1,N²-εdGuo and 1,N⁶-εdAdo in DNA from biological samples in different studies

Species/Model	Tissue	Method	Level	References
1,N²-εdGuo
Human cell line IMR-90	Lung	LC-ESI-MS/MS	0.2–1.8/10⁷ dGuo	[118]
Human cell line SW480	Colon adenocarcinoma	LC-ESI-MS/MS	0.5–2/10⁷ dGuo	[119]
Human cell line A549	Lung	LC-ESI-MS/MS	1.5–5/10⁶ dGuo	[45]
Rat	Liver	LC-ESI-MS/MS	1–3.25/10⁶ dGuo	[44]
Rat	Lung	LC-ESI-MS/MS	1.5–2.5/10⁶ dGuo	[44]
1,N⁶-εdAdo
Human	Lung	³²P-postlabeling	2.4–146/10⁹ dAdo	[139]
Human cell line A549	Lung	LC-ESI-MS/MS	0.1–0.45/10⁶ dGuo	[45]
Human	White Blood Cells	³²P-postlabeling	0.08–24.07/10⁸ dAdo	[140]
Human	White Blood Cells	³²P-postlabeling	138–1017/10⁹ dAdo	[141]
Human	White Blood Cells	³²P-postlabeling	0.03–90.15/10⁷ dAdo	[142]
Rat	Liver	LC-ESI-MS/MS	0.75–2/10⁶ dGuo	[44]
Rat	Liver	LC-ESI-MS/MS	2.1–6.9/10⁸ tdn	[143]
Rat	Lung	LC-ESI-MS/MS	0.5–1.25/10⁶ dGuo	[44]

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