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Table 1 Characterization of inhaled chemicals including nanomaterials

From: Usefulness of myeloperoxidase as a biomarker for the ranking of pulmonary toxicity of nanomaterials

Samples Toxicity Exposure route Characterization Animal (rats) Negative control Dose / Concentration Reference
NiO High IT / IH Size 19 nm, BET 57 m2/g Secondary particle diameter (DLS)59.7 nm Male Fischer344 Distilled water/Clean air 0.2 mg, 1.0 mg/0.32 ± 0.07 mg/m3, 1.65 ± 0.20 mg/m3 Morimoto et al [18] Oyabu et al [19]
CeO2 High IT / IH Size 7.8 nm, BET 101 m2/g Secondary particle diameter (DLS)10.0 nm Male Fischer344 Distilled water/Clean air 0.2 mg, 1.0 mg/2.09 ± 0.29 mg/m3, 10.2 ± 1.38 mg/m3 Morimoto et al [20]
SWCNT High IT Diameter 1.8 nm BET 878 m2/g Male Wistar Distilled water +0.1% Triton X-100 0.2 mg, 0.4 mg Morimoto et al [24]
MWCNT (S) High IT Diameter 48 nm Length 0.94 μm Male Wistar Distilled water +0.05% Triton X-100 0.2 mg, 1.0 mg Lee et al [22]
MWCNT (L) High IT Diameter 48 nm Length 3.4 μm Male Wistar Distilled water +0.05% Triton X-100 0.2 mg, 0.6 mg Lee et al [22]
TiO2(P90) Low IT Size 14 nm, BET 104 m2/g Secondary particle diameter (DLS)22.7 nm Female Wistar Distilled water 0.2 mg, 1.0 mg Yoshiura et al [17]
TiO2(Rutile) Low IT / IH Size 12 nm × 55 nm, BET 111 m2/g Secondary particle diameter (DLS)44.9 nm Male Fischer344 Distilled water/Clean air 0.2 mg, 1.0 mg/0.50 ± 0.26 mg/m3, 1.84 ± 0.74 mg/m3 Morimoto et al [18] Oyabu et al [19]
ZnO Low IT / IH Size 35 nm, BET 31 m2/g Secondary particle diameter (DLS)33 nm Male Fischer344 Distilled water/Clean air 0.2 mg, 1.0 mg/2.11 ± 0.45 mg/m3, 10.4 ± 1.39 mg/m3 Morimoto et al [21]
Toner Low IT Size 4.05 μm, BET 2–3 m2/g Including nanoparticles as external additives(Titanium dioxide and amorphous silica) Female Wistar Distilled water +0.1% Tween-80 1.0 mg Morimoto et al [25]
  1. IT intratracheal instillation, IH inhalation exposure