Table 1 Documented cytokine secretion profiles for pulmonary cells or tissues following exposure to biodiesel emissions
From: The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity
Study | Malorni et al. 2017 [92] | Fukagawa et al. 2013 [29] | Yanamala et al. 2013 [65] | Shvedova et al. 2013 [90] | ||||
|---|---|---|---|---|---|---|---|---|
Exposure | 20% FAME PM0.1 (organic fraction) | 20% SME Total PM | 100% FAME Total PM | 100% SME Total PM | ||||
Model | A549 | THP-1 | BEAS-2B | Mouse lung | Mouse BALF | Mouse lung | Mouse BALF | Mouse Lung |
bFGF | ↓ | – | – | N | N | – | – | N |
CCL5 (RANTES) | N | N | N | N | N | ↑ | ↑ | N |
CXCL1 (KC) | N | N | N | – | – | ↑ | ↑ | N |
CXCL9 (MIG) | N | N | N | N | N | ↑ | ↑ | N |
Eotaxin | ↓ | – | – | N | N | ↑ | – | N |
G-CSF | ↓ | ↑ | – | ↑ | ↑ | ↑ | ↑ | N |
GM-CSF | – | – | – | – | – | – | – | N |
IL-10 | – | – | – | – | – | – | – | ↑ |
IL-12p40 | – | – | – | N | N | ↑ | ↑ | N |
IL-12p70 | – | – | – | – | – | ↑ | ↑ | ↑ |
IL-13 | – | – | – | – | – | – | – | N |
IL-15 | ↓ | – | – | – | – | – | – | N |
IL-17 | ↓ | – | – | – | – | – | – | N |
IL-18 | N | N | N | N | N | – | – | N |
IL-1α | N | N | N | – | – | ↑ | ↑ | N |
IL-1β | – | – | – | – | – | ↑ | ↑ | N |
IL-1ra | – | – | – | N | N | N | N | N |
IL-2 | ↓ | – | – | – | – | – | – | N |
IL-3 | N | N | N | N | N | – | – | N |
IL-4 | – | – | – | – | – | ↑ | ↑ | N |
IL-5 | – | – | – | – | – | – | – | N |
IL-6 | ↓ | – | – | ↑ | ↑ | ↑ | ↑ | ↑ |
IL-7 | – | – | – | – | – | N | N | N |
IL-8 | – | – | ↑ | N | N | N | N | N |
IL-9 | – | – | – | – | – | – | – | N |
IFNγ | – | – | – | – | – | – | ↑ | – |
IP-10 | ↓ | – | – | ↑ | ↑ | – | – | N |
LIF | N | N | N | N | N | ↑ | – | N |
MCP-1 | – | – | ↑ | – | – | ↑ | ↑ | ↑ |
M-CSF | N | N | N | – | – | – | – | N |
MIP-1α | – | – | – | – | – | ↑ | ↑ | N |
MIP-1β | – | – | – | N | N | ↑ | ↑ | N |
MIP-2 | N | N | N | N | N | ↑ | – | N |
PDGF | ↓ | – | – | N | N | ↑ | – | N |
TNF-α | – | – | – | – | – | – | ↑ | ↑ |
VEGF | – | – | – | N | N | – | – | N |