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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation

Fig. 7

MWCNTs oxidized for 6 or more hours exacerbate the CHS ear swelling response. Mice were sensitized with 30 μl 0.05% DNFB in a 4:1 acetone/olive oil vehicle on the lower dorsum on day 0. On day 5 the mice were challenged with 20 μl per ear of 0.2% DNFB on the right ear (black bars) and 0.2% DNFB with 1 μg/ear of the different oxidized MWCNTs on the left ear (gray bars). Graphs represent the change in mean ear swelling, after 24 hours, (+/- SEM), N=5. Data were analyzed by a Student’s T-test, comparing the DNFB and DNFB + MWCNT groups. Significance is defined at a p-value < 0.05. # indicate significance compared to DNFB control

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