Table 6 Comparisons of nanoparticle collection via human (10 L/min) and rat (0.28 L/min, Sprague Dawley of 400 g) nasal olfactory (ambient nanoparticle concentration: n particles/L for each size)
From: Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory
Particle Diameter (nm) | Â | ||
|---|---|---|---|
| Â | Total Collection Rate: (#/min) x n | ||
Human | Rat | Rat/Human Ratio | |
1 | 0.232 | 0.00008 | 0.00035 |
2 | 0.221 | 0.0028 | 0.013 |
3 | 0.154 | 0.0088 | 0.057 |
5 | 0.081 | 0.0165 | 0.203 |
20 | 0.013 | 0.0082 | 0.633 |
50 | 0.003 | 0.0024 | 0.811 |
| Â | Olfactory Surface Collection Rate: (#/min/mm2) x n | ||
Human (x 1E-6) | Rat (x 1E-6) | Rat/Human Ratio | |
1 | 110.6 | 0.06 | 0.00057 |
2 | 105.4 | 2.15 | 0.02 |
3 | 73.4 | 6.80 | 0.09 |
5 | 38.6 | 12.74 | 0.33 |
20 | 6.2 | 6.36 | 1.03 |
50 | 1.4 | 1.88 | 1.31 |
| Â | Collection Rate Per Body Mass: (#/min/kg) x n | ||
| Â | Human (x 1E-4) | Rat (x 1E-4) | Rat/Human Ratio |
1 | 26.36 | 2.03 | 0.077 |
2 | 25.11 | 69.4 | 2.77 |
3 | 17.5 | 220.0 | 12.6 |
5 | 9.20 | 412.0 | 44.8 |
20 | 1.48 | 205.9 | 139.4 |
50 | 0.34 | 60.8 | 178.4 |