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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Silver nanoparticles promote procoagulant activity of red blood cells: a potential risk of thrombosis in susceptible population

Fig. 1

Characterization of AgNP and its cellular uptake by RBCs. a The size distribution histogram generated using SEM images showed AgNP of size between 0 and 100 nm with an average of 49.3 nm. Values are calculated from randomly measuring 118 AgNP taken by SEM. b Particle size distribution of AgNP in saline suspension used for intravenous injection showed particles of diameter ranging from 32.7 nm to 255 nm, with a peak of distribution at 125.4 nm. The results indicated the presence of AgNP agglomerates in saline. c Cellular uptake of various concentrations of AgNP by RBCs were observed using TEM after 4 h treatment. The red arrows indicated cell disruption and lysis at 500 μg/mL of AgNP. Magnifications were 25,000 (c, i- iii) and 80,000 (c, iv-vi) for 100 μg/mL AgNP. And the white arrows indicated AgNP uptaken by RBCs (n = 4)

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