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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations

Fig. 5

MMP gene and protein expression induced by exposure of 3D lung microtissues to test nanomaterials for 4 days. a Dose response of MMP1 and MMP3 gene expression analyzed using qRT-PCR. Statistical significance is indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 for comparisons between each dose relative to untreated microtissues. Statistical significance is indicated by #p < 0.05 for comparisons between the same dose of each of the three nanomaterials relative to untreated microtissues. b Expression of MMP proteins in microtissue protein lysates collected after exposure to test nanomaterials for 4 days. These experiments were repeated twice. ND = not detectable

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