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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials

Fig. 4

SWCNTs induced lung injury. Inhalation of SWCNTs could up-regulate chemokines, proteinases and several macrophage receptors, also resulting in NF-κB-related inflammatory responses, which play roles in lung pathology including airway hyperreaction, airflow obstruction and granuloma. In vitro experiments indicated that the cell-cell interaction of bronchoalveolar macrophages with lung epithelial cells induced MMP12 and cathepsin K. Blocking NF-κB with PDTC could attenuate SWCNTs-induced chemokine and proteinase expression

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