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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Fig. 4

Effects of SiNPs on vascular oxidative damage, NO/NO system and vascular function. The level of MDA (a) was increased, while the activities of SOD (b) and GSH-Px (c) were decreased in a dose dependent manner. The activity of NO (d) and eNOS (f) decreased markedly and the activity of iNOS (e) increased with increasing SiNPs. Effect of SiNPs on tissue factor (TF) expression in aortic arch sections were detected by immunohistochemical analysis (g). Expression of TF increased in a dose-dependent manner by SiNPs (h). Data were expressed as means ± S.D. from six independent experiments. *p < 0.05 and **p < 0.01 compared with control without SiNPs and any mimics/inhibitor

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