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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Fig. 5

Effects of SiNPs on coagulation function. Decreased TT (a) and APTT (b) demonstrating a trend towards increased blood coagulation in response to high concentration of SiNPs. Increased FIB (c) and shortened PT (d) are associated with increased blood viscosity and hypercoagulation. Increased TF (e) and FXa (f) demonstrated the activation of exogenous and endogenous coagulation systems. Increased vWF (g), PLT (h) and D2D (l) were detected. The anti-coagulative and fibrinolytic system were inhibited by decreasing AT III (i), TFPI (j) and t-PA (k). Data were expressed as means ± S.D. from six independent experiments. *p < 0.05 and **p < 0.01 compared with control without SiNPs and any mimics/inhibitor

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