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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Fig. 7

The role of SiNPs-triggered miR-451a on IL6R/STAT/TF signaling pathway in vivo. Decreased miR-451a and increased genes expression of Il6r, Jak1, Stat3, Tf and Fib were detected after SiNPs exposure (a-f). Protein levels of JAK1, STAT3, TF, IL6R, FIB and vWF were significantly increased in a dose-dependent manner induced by SiNPs (g). The protein levels of JAK1, STAT3, TF, IL6R, FIB and vWF were caculated by the relative densitometric analysis (h). Data are expressed as means ± S.D. from six independent experiments. *p < 0.05 and **p < 0.01 compared with control without SiNPs and any mimics/inhibitor

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