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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Fig. 8

The effects of plasmid transfection with miR-451a mimics in SD rats exposed to SiNPs. Decreased miR-451a and increased genes expression of IL6R, JAK1, STAT3, TF and vWF were detected after SiNPs exposure (a-f). Protein levels of IL6R, JAK1, STAT3, TF and vWF were significantly decreased in miR-451a mimics + SiNPs group (g). The protein levels of IL6R, JAK1, STAT3, TF and vWF were calculated by the relative densitometric analysis (h). Data are expressed as means ± S.D. from six independent experiments. *p < 0.05 and **p < 0.01 compared with negative control group

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