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Table 2 Top ten pathways showing significantly altered transcription as identified by Ingenuity Pathway Analysis (Qiagen). Arrows indicate expression in DE samples compared to FA

From: In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation

Ingenuity Canonical Pathway

p-value

Molecules

Mitochondrial L-carnitine Shuttle Pathway

2.14E-06

↓Slc27a1, Acsl1, Cpt1A, Cpt2, Cpt1B

Fatty Acid β-oxidation

3.47E-06

↓Slc27a1, Acaa2, Acsl1, Hadha, Eci2, Hadhb

AMPK Signaling

4.68E-06

↓Mlycd, Adra1B, Pik3r3, Cpt1A, Acacb, Lipe, Cpt2, Cpt1B

↑Adra2a, Ccnd1, Pfkl, Slc2a1

Cell Cycle Control of Chromosomal Replication

2.51E-05

↑Cdc45, Mcm2, Mcm3, Mcm6, Mcm5

LPS/IL-1 Mediated Inhibition of RXR Function

4.17E-05

↓Slc27a1, Hmgcs2, Aldh9a1, Acsl1, Ppargc1b, Fabp3, Cat, Cpt1A, Cpt2, Cpt1B

↑Chst12, Fabp5

GADD45 Signaling

1.00E-04

↑Ccne1, Ccnd1, Pcna, Cdk1

Hepatic Fibrosis / Hepatic Stellate Cell Activation

1.70E-04

↑A2m, Igfbp4, Pgf, Col27a1, Col5a3, Igfbp3, Col1a1, Ccl21

↓Fgf1, Myh6

Ketogenesis

2.57E-04

↓Hmgcs2, Hadha, Hadhb

Estrogen-mediated S-phase Entry

2.57E-04

↑Ccne1, Ccnd1, E2f1, Cdk1

Oleate Biosynthesis II (Animals)

5.89E-04

↓Scd4

↑Fads1