In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation

Table 5 Top ten pathways with altered DNA methylation. All molecules listed have shown decreased methylation in the associated DMRs

Ingenuity Canonical Pathway	p-value	Molecules
Cardiac Hypertrophy Signaling	0.002	Map3k9, Gnas, Adra2c, Gng12
G_αs Signaling	0.002	Rapgef2, Gnas, Gng12
G Protein Signaling Mediated by Tubby	0.003	Gnas, Gng12
G_αi Signaling	0.003	Gnas, Adra2c, Gng12
Cardiac β-adrenergic Signaling	0.004	Gnas, Gng12, Pde6h
Relaxin Signaling	0.004	Gnas, Gng12, Pde6h
Ephrin Receptor Signaling	0.008	Epha7, Gnas, Gng12
CCR5 Signaling in Macrophages	0.012	Gnas, Gng12
Ephrin B Signaling	0.013	Gnas, Gng12
Protein Kinase A Signaling	0.014	Ptpru, Gnas, Gng12, Pde6h

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