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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

Fig. 2

Daily fecal excretion as 48V fractions of intratracheally inhaled [48V]TiO2-NP. Panel a: Daily fecal excretion of intratracheally inhaled [48V]TiO2-NP normalized to the total deposited [48V]TiO2-NP lung dose (ILD) present in the lungs 2 h p.e., representing MCC from the conducting thoracic airways during the first two days after inhalation and thereafter LT-MC from the alveolar region. The mean ILD in mass (number) of [48V]TiO2-NP of all five retention time points is 1.36 ± 0.45 μg (3.59 ± 1.08•1010 #). Data of the groups of rats analyzed 7 days and 28 days p.e. are presented. For the 28 days group, fecal excretions sampled over 3–4 days are divided by the number of sampling days and associated with the mean day of the sampling period. Panel b: Cumulative fecal excretion without MCC of the 7 days and 28 days group. Panel c: The excretion rates are normalized to contemporary lung retention (CLR) at each dissection time point. The CLR was obtained from an exponential fit to the lung fractions (sum of lavaged lungs, BALF and BALC) at each dissection time point (see Eq. (1a) and (1c) of the Additional file 1). Mean ± SEM, n = 4 rats per time point

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