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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

Fig. 3

Daily urinary excretion as 48V fractions of intratracheally inhaled [48V]TiO2-NP. Panels a + b: Daily urinary excretion as 48V fractions of intratracheally inhaled [48V]TiO2-NP of the 7 days and 28 days group. Data are given as fractions of IPLD. The mean IPLD in mass (number) of [48V]TiO2-NP of all five retention time points is 1.01 ± 0.55 μg (2.67 ± 1.16•1010 #). For the 28 days group, the urine sampled over 3–4 days are divided by the number of sampling days and associated with the mean day of the sampling period. Mean ± SEM, n = 4 rats per time point. Panel c: Translocated [48V]TiO2-NP across the ABB presented as stacked columns with accumulation in major secondary organs, soft tissue, skeleton, and cumulative urine. While translocated [48V]TiO2-NP accumulated predominantly in soft tissue up to 24 h the fraction released in urine increases rapidly from day 7 to day 28 p.e. Mean ± SEM, n = 4 rats per time point

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