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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

Fig. 9

Comparison of interstitial relocation and epithelial re-entrainment for nano- and micron-sized particles. Estimated [48V]TiO2-NP retention fractions for the total lung surface macrophage pool [26] (for the definition of the AM pool, see the Additional file 1) derived from the experimentally determined kinetics of lavageable [48V]TiO2-NP fractions associated with BALC (downward triangles). Additionally, the [48V]TiO2-NP fractions found in the interstitium, estimated from [48V]TiO2-NP fractions of lavaged lungs (diamonds) are shown. Fractions are normalized to the contemporary lung burden at 1 h to 28 days after intratracheal inhalation. Additionally, the fractions of free [48V]TiO2-NP in BALF are presented, which rapidly decline p.e. (upward triangles). These data are compared with averaged retention fractions for 20 nm [192Ir] IrNP and [195Au] AuNP in the total AM pool [23, 25, 26] and with those of 1.3 μm fused aluminum-silicate particles (FAP) particles and 2.1 μm polystyrene (PSL) particles in the total AM pool [45, 46]. Data points are mean ± SEM; n = 4 rats per time point

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