
GITabsorbed NP fraction after NP gavage [23]

Estimated NP fraction of GITabsorption cleared from lungs

Ratio: GITabsorb. NP over measured fractions after NP inhalation


2nd organs

24 h

7d

24 h

7d

24 h

7d


liver

1.27E04

2.26E05

1.21E07

4.62E08

4.53E03

5.67E03

spleen

3.19E05

1.16E05

1.68E09

2.37E09

2.50E04

5.65E04

kidneys

3.82E05

2.30E05

2.74E08

3.19E08

3.42E03

3.86E03

heart

7.96E05

4.89E06

2.78E09

2.24E10

1.66E04

1.27E04

brain

1.01E05

2.38E05

7.66E11

1.12E09

3.59E05

1.31E04

uterus

2.44E05

4.37E05

1.43E09

3.61E09

2.77E04

2.29E04

carcass

8.07E04

2.88E04

5.82E06

4.51E06

3.42E02

4.34E02

skeleton

4.39E04

8.96E04

1.87E06

7.09E06

2.02E02

2.20E02

soft tissue

4.58E04

5.00E06

1.40E06

3.86E08

1.45E02

2.15E02

 Mean values of GITabsorbed fractions after [^{48}V]TiO_{2}NP gavage in the left two columns at 24 h or 7 days were taken from [23]. Estimated contribution of GITabsorption of [^{48}V]TiO_{2}NP cleared from lungs were calculated by multiplying the mean values of [^{48}V]TiO_{2}NP cleared after 24 h by MCC into the GIT and the sum of all [^{48}V]TiO_{2}NP which had entered the GIT within the first 7 days p.e. (Table 2) and the fraction in the according left column of the Table 4. These are shown in the middle columns of Table 4. The ratios of GITabsorbed [^{48}V]TiO_{2}NP at 24 h or 7 days divided by the mean values of the measured organ or tissue fractions of Table 3 after [^{48}V]TiO_{2}NP inhalation are presented in the right columns of Table 4. These ratios confirm the rather low contribution of GITabsorbed [^{48}V]TiO_{2}NP to the measured accumulation of each secondary organ or tissue in Table 3