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Table 1 Identified sequences within the MWCNT-induced peptidome

From: Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction

Peptide_Sequence

Parent_Protein_Name

Symbol

Accession

Homo-logue

Source

Peptide Mass

Precursor Mass

Prec. RTa

Prec. DTb

Prec. Merrc

Prod. Merrd

Peptide Score

FDR

QDALSGSSDLLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASLTRSSQSSHTSKYFGSLD

Period circadian protein homolog 1

Per1

O35973

 

MEROPS

6731.1214

6750.1381

40.42

54.58

0.25

2.57

7.679

0.000

SFDQVDPVQSTFPTETGGLST

von Willebrand factor D and EGF domain-containing protein

Vwde

A0A0N4SVZ4

 

SignalP

2194.0066

2213.0318

39.54

46.69

3.11

3.28

7.510

0.000

TERFGQGGAGPVGGQGPRGMGPGT

Splicing factor proline- and glutamine-rich

Sfpq

Q8VIJ6

 

MEROPS

2209.0446

2228.0428

39.21

47.91

9.16

3.65

7.448

0.000

RYTQKAPQVSTPTLVEAARNLGRVGTKC

Serum albumin

Alb

P07724

 

MEROPS, SignalP

3082.6458

3101.6650

29.18

51.67

0.27

5.34

7.275

0.000

GRPERQFFVKWQGMSYWHCSWVSELQ

Chromodomain-helicase-DNA-binding protein 4

Chd4

Q6PDQ2

 

MEROPS

3309.5389

3328.5559

34.18

52.67

0.42

5.62

7.256

0.000

KDTCFSTEGPNLVTRCKD

Serum albumin

Alb

P07724

 

MEROPS, SignalP

2108.9619

2127.9844

18.90

45.86

1.94

5.90

7.239

0.000

CKAADKDTCFSTEGPNLVTRCKD

Serum albumin

Alb

P07724

 

MEROPS, SignalP

2654.1887

2673.2104

18.12

53.79

1.25

5.91

7.238

0.000

PAGANGEKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGA

Collagen alpha-1(II) chain

Col2a1

P28481

 

MEROPS, SignalP

6659.1069

6678.1019

36.86

52.51

3.51

5.98

7.234

0.000

NKGPVKVVVGKTF

Protein disulfide-isomerase A4

Pdia4

P08003

 

MEROPS

1353.8132

1372.8346

32.85

63.44

2.20

6.41

7.212

0.000

PPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGL

Receptor-interacting serine/threonine-protein kinase 1

Ripk1

Q60855

 

MEROPS

6499.9588

6518.9949

38.98

52.98

2.73

6.81

7.194

0.000

KCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYLRDL

Chondroitin sulfate synthase 1

Chsy1

Q6ZQ11

 

SignalP

6563.0918

6582.0918

36.11

52.00

2.81

7.39

7.171

0.000

KDRGHREEGEDFSREYGHRVQDHRYPG

Histidine rich calcium binding protein isoform CRA_a

Hrc

G5E8J6

 

SignalP

3293.5211

3312.5554

44.06

52.77

4.82

7.40

7.170

0.000

VCTAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRT

Dickkopf-related protein 4

Dkk4

Q8VEJ3

 

SignalP

6607.0786

6626.1046

40.69

57.90

1.15

7.76

7.158

0.000

MNLEEKPAPAA

Apolipoprotein A-II

Apoa2

P09813

 

SignalP

1151.5645

1170.5826

17.71

46.99

0.23

7.87

7.154

0.000

TMNNEKYPVNLSETRLGWNSFNCSLSKNSNKKDHFTFNNTLEWTARNNFDMVLSE

Protein Vmn2r13

Vmn2r13

L7N1X2

 

SignalP

6524.0437

6543.0484

37.20

52.69

2.10

8.26

7.142

0.000

TSVPKRRRPSGNGGFLGDPYCSESPQESSCEDGEGSSVMSARQRSAAESSKLSCSDVPDLVR

DNA repair protein complementing XP-G cells homolog

Ercc5

P35689

 

MEROPS

6685.0674

6704.1050

37.74

53.39

2.88

8.50

7.135

0.000

KPSGLVMARKLLHLELKPAL

Dual specificity mitogen-activated protein kinase kinase 1

Map2k1

P31938

 

MEROPS

2195.3340

2214.3732

41.79

47.98

9.48

9.58

7.109

0.000

YYVDSEGNRLSGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRALYQATYRDAYSG

Proteasome subunit beta type-5

Psmb5

O55234

 

MEROPS

6677.1145

6696.1121

38.75

53.55

3.12

9.67

7.107

0.000

DLKLCDFGLARVADPDHDH

Mitogen-activated protein kinase 1

Mapk1

P63085

 

MEROPS

2175.0167

2194.0272

37.28

47.00

3.62

10.35

7.093

0.000

GKEAYAEYHFRVGSEAEGYALQVSSY

Fibrinogen alpha chain

Fga

E9PV24

 

MEROPS

2892.3354

2911.3501

26.92

50.14

1.29

10.95

7.083

0.000

SLCDLPVHSNKEWSQHLNGASHSRRCQLLLELYPEWNPDNDTGHTMGDPFMLQQSTN

Matrin-3

Matr3

Q8K310

 

MEROPS

6642.0386

6661.0724

41.86

53.01

2.32

11.24

7.078

0.000

ELFQREVSSVELFSYA

UDP-glucuronosyltransferase

Ugt1a5

B2RT14

 

SignalP

1884.9258

1903.9390

30.24

88.84

2.73

11.73

7.071

0.000

RPCPTEQLSPSHPPLATCFGSDVDLQLEMAVPQPGQYVLVVEYVGEDSHQEMGVAVHTPQ

Laminin subunit alpha-5

Lama5

Q61001

 

MEROPS

6608.1184

6627.1148

39.56

58.20

3.33

12.10

7.065

0.000

YLPSGQQLYMSKEM

MCG3425

Vmn2r75

G5E8Z7

 

SignalP

1655.7688

1674.7799

39.43

53.63

4.38

12.62

7.058

0.000

SFDWLMEQKFDMTFSENSHNLYNAVHALAHALHEMNLQQADNQALGNGKGASSHCLKVNS

Protein Gm10302

Vmn2r47

K7 N709

G3UYU1,K7N5W1

SignalP

6737.1121

6756.1282

40.75

54.32

0.34

12.95

7.054

0.000

AMDVQLHSPAFQFPDVDFLREGEDDRTVCKELRRNSTGCLKMKGQCEKCQELLSVDCS

Clusterin

Clu

Q06890

 

MEROPS

6871.1801

6890.2217

39.42

55.38

3.38

13.42

7.049

0.000

KLQCENVQDMPVFG

Disintegrin and metalloproteinase domain-containing protein 9

Adam9

Q61072

E9Q638

SignalP

1645.7592

1664.7772

34.40

53.13

0.26

13.81

7.045

0.000

GPQGQFRAPGPQGQMGPQGPPMHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPH

pre-mRNA 3′ end processing protein WDR33

Wdr33

Q8K4P0

 

MEROPS

6509.0183

6528.0352

36.48

52.40

0.24

11.24

7.044

0.000

KEEEEQRRAEEQMLKERE

Eukaryotic translation initiation factor 3 subunit A

Eif3a

P23116

 

MEROPS

2328.1128

2347.1170

24.79

49.11

6.10

13.98

7.043

0.000

ELVVQDGVTLLTKDEGPGSSLT

X-ray repair cross-complementing protein 5

Xrcc5

P27641

 

MEROPS, SignalP

2239.1583

2258.1794

25.42

43.46

1.20

15.06

7.033

0.000

LNELDFYEAFMEEPMTLPDKPNSEEELVSFVEEHRRSTLRKLKPESMYETWEDD

Calsequestrin-1

Casq1

O09165

 

SignalP

6560.0450

6579.0482

39.19

52.73

2.31

16.35

7.022

0.000

SEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDLQDNKFLEAGQFNDNL

Disks large homolog 3

Dlg3

P70175

 

MEROPS

6645.1002

6664.1136

31.59

55.15

0.76

18.09

7.011

0.000

QQRGRSCDVTSNTCLGPSLQTRTCSLGKCDTRLRQNGGWSHWSPWSSCSVTCGVGNVTR

Thrombospondin-2

Thbs2

Q03350

 

MEROPS

6737.0870

6756.1282

40.75

54.32

3.38

12.95

6.965

0.000

GKMCFQTLTDDDYKSELR

Ephrin type-B receptor 1

Ephb1

Q8CBF3

 

MEROPS

2187.9929

2207.0319

38.08

46.90

9.43

16.34

6.879

0.017

GCYYYWNTQTNEVTWELPQYLATQVQGLQHYQPSSVTGTEAAFVVNTDMYTKERTT

Formin-binding protein 4

Fnbp4

Q6ZQ03

 

MEROPS

6549.0270

6568.0537

38.36

53.02

1.26

14.37

6.879

0.017

VPFDGMWLDMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGLLQAATLCASSHQFLSTHY

Lysosomal alpha-glucosidase

Gaa

P70699

 

MEROPS

6614.0616

6633.0737

39.13

53.55

0.95

14.82

6.874

0.017

GYAANYCDGECSFPLNAHMNATNHALVQTLVHLMNPEYVPKPCCAPTKLNALSVLYFDD

Bone morphogenetic protein 6

Bmp6

P20722

 

SignalP

6693.0782

6712.1155

37.19

58.90

2.83

12.66

6.869

0.017

GSGEQYRGSVSKTRKGVQCQHWSSETPHKPQFTPTSAPQAGLEANFCRNPDGDSHGPWC

Hepatocyte growth factor-like protein

Mst1

E0CXN0

P26928

SignalP

6577.9900

6597.0184

41.81

53.73

1.52

9.93

6.851

0.017

SCDSALRAYVKDHYSNGFCTVYAKTLDGQQTLLACLESHQFQPKNFWNGRWRSEW

F-actin-capping protein subunit alpha-1

Capza1

P47753

 

MEROPS

6607.0861

6626.1144

41.74

52.74

1.49

17.04

6.846

0.017

GNVKMTLGMLWTLL

Alpha-actinin-1

Actn1

Q7TPR4

 

MEROPS

1557.8411

1576.8527

46.69

71.65

4.37

11.30

6.804

0.017

YPGQAPPGAYPGQAPPSAYPGPTAPGAYPGPTAPGAYPGQPAPGAFPGQPGAPGAYPQCSGGYPAAGPYGV

Galectin-3

Lgals3

P16110

 

MEROPS

6672.0973

6691.0977

39.09

53.61

2.70

12.38

6.801

0.029

TQAFYRVDLSLDFAEMDSPVHWTVE

Protein Gm572

Gm572

B1ARY8

 

SignalP

2937.3643

2956.3656

26.01

45.98

5.82

13.96

6.800

0.029

FGSGQSSGLTSVSGETSGLSDLSG

Aggrecan core protein

Acan

Q61282

 

MEROPS

2197.9975

2217.0301

39.32

46.73

6.47

14.94

6.788

0.029

FKASDLDGDLTATREEFTAF

Reticulocalbin-1

Rcn1

Q05186

 

MEROPS

2215.0433

2234.0482

38.26

48.00

6.09

13.30

6.770

0.029

LYKLDDPSCPRPECYRSCGSSTPDEFPTDLPGTKGNFKLVRHVSFVDCPGHDLLMATM

Eukaryotic translation initiation factor 2 subunit 3 X-linked

Eif2s3x

Q9Z0N1

 

MEROPS

6652.0840

6671.0899

38.48

52.88

1.88

13.61

6.767

0.029

VDTSFVEVTPTTFREEEGLGSVELSGFPSGETELSGTSGTVDVSEQSSGALDSSGLTSPTPEFSGL

Aggrecan core protein

Acan

Q61282

 

MEROPS

6665.0991

6684.0975

40.09

53.32

3.00

9.91

6.733

0.029

AEFQPLVEEPKNLVKTN

Serum albumin

Alb

P07724

 

MEROPS

1937.0258

1956.0455

30.40

47.82

0.68

13.34

6.662

0.037

ESNTNPTGWEPNEENEDETDKYPSFSGSG

CD44 antigen

Cd44

A2APM2

 

SignalP

3198.2810

3217.2710

36.64

74.43

8.87

12.00

6.655

0.037

RYNQLYTYGYGSVARYNSYQSFQTPQHPSFLFKDKQLSWSATYLPTMQSCWNYGF

Galectin-3-binding protein

Lgals3bp

Q07797

 

MEROPS

6656.0848

6675.0796

41.58

53.17

3.54

16.89

6.651

0.037

KWNPETVESPGGVEDSQQCLEVEEGPEREQHQESLRSLGEVEWELPGSGSQQRWEDVV

Nestin

Nes

Q6P5H2

 

MEROPS

6642.0541

6661.0878

39.38

53.41

2.30

11.11

6.639

0.037

RPSTMLCAGYLAGGLDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVT

Serine protease 56

Prss56

F2YMG0

 

SignalP

6508.0191

6527.0477

38.22

52.51

1.57

15.34

6.634

0.037

STPTPTTTASSTASGSAPNPTTTVSSTASGSTPTLPTTASSSGSGSTPTLTTTESSTASGSSPTLTTTASSSA

Protein Gm9573

Gm9573

F7C950

 

SignalP

6651.0814

6670.0954

38.21

53.40

0.65

15.36

6.631

0.037

SDGSSTPARATVTLNVTDVNDN

Protein Pcdh9

Pcdh9

F8VPK8

A0A0A6YY09,A0A0A6YWY8,A0A0A6YWM0

SignalP

2215.0353

2234.0482

38.26

48.00

2.46

13.22

6.579

0.045

FKQDVFDFPACDVFTVEPGFDAALGQYLC

Nuclear pore membrane glycoprotein 210

Nup210

A0A0R4J1I6

Q9QY81

SignalP

3337.5100

3356.5521

38.87

53.46

7.12

16.52

6.536

0.045

VVFVVLVLVLTGSLVALAYLCVLPLLLRTY

Probable palmitoyltransferase ZDHHC16

Zdhhc16

Q9ESG8

 

SignalP

3297.9905

3317.0398

38.64

53.00

9.36

15.75

6.529

0.045

AEFQPLVEEPKNL

Serum albumin

Alb

P07724

 

MEROPS

1494.7718

1513.7940

32.87

66.55

2.54

15.89

6.524

0.045

AEFQPLVEEPKNLVKTNCDLYEKLGEYGFQNA

Serum albumin

Alb

P07724

 

MEROPS, SignalP

3724.8083

3743.8424

40.63

64.11

4.23

18.08

6.520

0.052

FSSLMNLEEKPAPAA

Apolipoprotein A-II

Apoa2

P09813

 

SignalP

1585.7810

1604.8040

31.21

70.02

2.90

15.31

6.505

0.052

LTSELTDERNTGESASQLLDAETA

Unconventional myosin-XVIIIa

Myo18a

Q9JMH9

 

MEROPS

2532.1827

2551.1922

25.56

52.97

3.51

15.23

6.495

0.052

KARENPSEEAQNLVEFTDE

Splicing factor 3A subunit 3

Sf3a3

Q9D554

 

MEROPS

2187.0080

2206.0304

38.60

47.30

1.84

14.08

6.462

0.059

DLVCSPVWTSRDRCCDLPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGER

Collagen alpha-1(XII) chain

Col12a1

E9PX70

Q60847–5

SignalP

6581.0473

6600.0596

41.29

53.48

0.93

12.69

6.449

0.059

RGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPAN

Protein-glutamine gamma-glutamyltransferase 2

Tgm2

P21981

 

MEROPS

6554.0731

6573.0724

38.80

52.57

2.92

17.55

6.381

0.067

HPPPTSREDKSPSEESTTTTSPESLSGSVPSSG

UV excision repair protein RAD23 homolog A

Rad23a

P54726

 

MEROPS

3336.5229

3355.5558

37.44

53.13

4.34

16.09

6.337

0.080

GRNQASAGSAPGAVLSQAMESTAVRPEETPRGLGDGLESSGTVQEPDAGGSSLEQDSQKQAEEKEQ

Scavenger receptor class F member 1

Scarf1

Q5ND28

 

SignalP

6678.1247

6697.1335

36.12

52.95

1.44

18.93

6.328

0.080

KSQPKKFCDYCKCWLADNRPSVEFHE

WW domain-binding protein 4

Wbp4

Q61048

 

MEROPS

3310.5110

3329.5493

39.73

53.65

6.01

14.28

6.327

0.080

TDGSFRCECPMGYNLDYTGVRCVDTDE

Fibrillin-2

Fbn2

Q61555

 

MEROPS

3198.2787

3217.2710

36.64

74.43

8.16

12.38

6.304

0.084

SSERVSGAEPAPGTMSKHRGKPSAACRCCVTYCEGESHLRSKSRAEMHTHPQWETHL

Isoform 3 of Interleukin-1 receptor accessory protein

Il1rap

Q61730–3

 

SignalP

6499.9797

6518.9949

38.98

52.98

0.48

14.82

6.285

0.084

LPFKNL

Cholesterol side-chain cleavage enzyme mitochondrial

Cyp11a1

Q9QZ82

 

MEROPS

712.4272

731.4462

52.82

109.68

0.87

17.99

6.244

0.094

NGLCVNSRGSFKCECPNGMTLDATGRLCLDLRLETCFLKYDDEECTLPLAGRHRMDA

Fibrillin-1

Fbn1

Q61554

 

MEROPS

6674.0571

6693.0873

39.87

53.46

1.76

13.49

6.228

0.094

NGRLTCTSRNRCNDQDTRTSYRLGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA

Fibronectin

Fn1

P11276

 

MEROPS

6596.0482

6615.0780

39.84

53.14

1.72

17.33

6.212

0.094

TVNPYTYPEDDYLPKFWVFFFKCSFSEFDCQLLENCQPNASLDLLPRHLFDPAMS

Protein Vmn2r62

Vmn2r62

K7 N712

 

SignalP

6690.0785

6709.0974

42.18

53.73

0.08

17.11

6.206

0.094

KSGVGGMGGYPGPAGPPGPPGPPGSS

Collagen alpha-1(III) chain

Col3a1

P08121

 

MEROPS

2200.0371

2219.0434

41.73

48.05

5.49

18.01

6.165

0.095

SSLDGLLTEHGPFLL

Lysosomal protective protein

Ctsa

P16675

 

MEROPS, SignalP

1579.8246

1598.8403

25.28

37.22

1.69

12.40

6.162

0.095

CSGSLVERRPCFSALTVD

Serum albumin

Alb

P07724

 

MEROPS

2034.9615

2053.9827

29.23

47.08

1.38

11.05

6.072

0.097

LVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPLLTSGDSDLS

Hepatocyte growth factor receptor

Met

F8VQL0

P16056

SignalP

6645.1187

6664.1136

31.59

55.15

3.54

11.68

6.071

0.097

PFPTFSSTAVMAKETTAFEEGEGSTYTPSEGRLMTGSERVPGLETTPVGTSYPPGALTDQEVE

Versican core protein

Vcan

Q62059

 

MEROPS

6606.0893

6625.0931

41.40

52.72

2.22

14.43

6.067

0.097

KLLLAFSLLLVLLLFQEQL

Protein Vmn2r23

Vmn2r23

E9PXI5

 

SignalP

2195.3697

2214.3732

41.79

47.98

6.78

17.75

6.050

0.101

ELETSHLGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFE

Calsyntenin-1

Clstn1

Q9EPL2

 

MEROPS, SignalP

6644.0520

6663.0569

38.66

52.84

2.03

11.98

6.032

0.101

QATTQPSTTAGTSTTTTTTTTAA

Ubiquilin-2

Ubqln2

Q9QZM0

 

MEROPS

2182.0237

2201.0355

39.22

47.21

3.03

13.97

6.025

0.101

PPASVVVGPVVVPR

Alpha-2-HS-glycoprotein

Ahsg

Q3UEK9

P29699

SignalP

1353.8132

1372.8346

32.85

63.44

2.21

11.64

5.985

0.101

EEAPQPALPFQPDSPTHFTP

Isoform 3 of Seizure protein 6

Sez6

Q7TSK2–3

 

SignalP

2187.0272

2206.0278

36.80

47.80

8.16

17.75

5.964

0.105

ATADAGSLSPRTCAALQKALDDDNDEKVSGSSDDLAEKMLLGSGLEQEEHADETAERGGGVPFD

DNA repair protein complementing XP-G cells homolog

Ercc5

P35689

 

MEROPS

6628.0364

6647.0762

38.70

52.58

3.22

17.40

5.952

0.105

  1. aPrecursor retention time
  2. bPrecursor drift time
  3. cPrecursor mass error in ppm
  4. dMaximum product mass error in ppm
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Particle and Fibre Toxicology

ISSN: 1743-8977

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