Particle type | Measurement | Instruments/Method | Relevant figures | |
---|---|---|---|---|
Non-commercial airfield particles (JEP) | Exposure characterization | 1 ELPI | Figure 1: | Exposure characterization |
4 DISCminis | Table 2: | Exposures and doses | ||
1 NanoScan | Additional File 1: Figure S1 A: | Position of instruments Jet engine test facility | ||
1 OPC | Additional File 1: Figure S1 B: | |||
Background characterization | Micro INertial Impactor (MINI) | Results not shown | ||
Emission characterization | Micro INertial Impactor (MINI) | Additional File 1: Figure S1 C: | Description of impacted aerosols and TEM images | |
Particle collection for physical and chemical characterization and mouse instillations | Electrostatic precipitator | Table 3: | PAH contents Metal contents | |
Table 4: | ||||
JEP particles suspended in instillation vehicle | TEM (dropcast) | Table 5: | Size distribution | |
Additional File 1: Figure S1 D: | DLS figures | |||
Fig. 2: | SEM images | |||
Additional File 1: Figure S1E: | Elemental composition by EDS analysis | |||
Commercial airport particles (CAP) | Exposure characterization | 4 DISCminis | Figure 1: | Exposure characterization |
1 NanoScan | Additional File 1: Figure S1 A: | Position of instruments | ||
1 OPC | Â | Â | ||
Emission characterization | Micro INertial Impactor (MINI) | Additional File 1: Figure S1 C: | Description of impacted aerosols and TEM images | |
Particle collection for physical and chemical characterization and mouse instillations | Electrostatic precipitator | Table 3: | PAH contents | |
Table 4: | Metal contents | |||
CAP particles suspended in instillation vehicle | TEM, dropcast | Table 5: | Size distribution | |
Additional File 1: Figure S1 D: | DLS figures | |||
Figure 2: | SEM images | |||
Additional File 1: Figure S1 E: | Elemental composition by EDS analysis | |||
Mouse instillations of JEP and CAP | Lung pathology | Histology | Figure 3: | Histopathology of lung sections |
Cellular composition in the lungs | Broncho-alveolar lavage (BAL) | Table 6: | BAL fluid cell composition | |
Figure 4: | Dose-response relationship of instilled particles | |||
Figure 5: | Neutrophil influx | |||
Additional File 2: Figure S2 A: | Scatter plots of cellular influx Eosinophil influx | |||
Serum Amyloid A levels in tissues | mRNA expression | Figure 6: | SAA day 1 | |
Additional File 2: Figure S2 B: | SAA day 28 and 90 | |||
DNA damage | DNA strand breaks (Comet Assay) | Figure 7: | Tail Length | |
Additional File 2: S2C: | % DNA in Tail and data table |