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Table 6 BAL fluid cell composition on day 1, 28 and 90 post-exposure

From: Airport emission particles: exposure characterization and toxicity following intratracheal instillation in mice

 

Total cell count

Neutrophils

Macrophages

Eosinophils

Lymphocytes

Epithelial cells

Day 1

      

 Vehicle control

56.43 ± 6.42

2.84 ± 0.89

46.58 ± 6.00

1.16 ± 0.79

0.84 ± 0.47

5.00 ± 1.59

  CB 54 μg

144.80 ± 16.23(****)

100.11 ± 11.85(****)

28.52 ± 3.05

9.96 ± 2.58(***)

1.43 ± 0.43

3.85 ± 0.78

  CAP 6 μg

53.32 ± 9.87

6.43 ± 0.88

42.62 ± 8.90

0.30 ± 0.07

0.04 ± 0.04

3.94 ± 1.65

  CAP 18 μg

82.22 ± 11.96

36.72 ± 10.00(***)(¤)

38.28 ± 2.94

1.40 ± 0.42

0.33 ± 0.15

5.49 ± 1.60

  CAP 54 μg

147.50 ± 10.64(****) (¤¤¤¤)(“’)

101.09 ± 11.07(****) (¤¤¤¤)(“’)

38.79 ± 5.78

1.85 ± 0.58(*) (“)

0.67 ± 0.30

5.10 ± 1.24

  JEP 6 μg

66.37 ± 21.58

6.29 ± 3.00

43.83 ± 7.92

10.01 ± 9.69

1.46 ± 1.26

4.77 ± 1.40

  JEP 18 μg

91.02 ± 9.67

25.89 ± 8.57(*)

57.40 ± 3.43(xx)

1.58 ± 0.63

1.01 ± 0.38

5.15 ± 1.40

  JEP 54 μg

160.50 ± 17.40(****)

(¤¤¤¤)(“’)

110.88 ± 14.66(****)

(¤¤¤¤)(“’)

37.40 ± 6.94

4.27 ± 1.75(*)

(“)

3.31 ± 1.05(¤)

(“’)

4.65 ± 0.97

  NIST2975 18 μg

47.92 ± 7.36

1.67 ± 0.46

42.05 ± 7.23

0.17 ± 0.09

0.19 ± 0.12

2.68 ± 0.51

  NIST2975 54 μg

61.50 ± 9.22

25.57 ± 5.82(*)

31.28 ± 3.61

1.05 ± 0.41

0.93 ± 0.27

3.48 ± 0.75

  NIST2975 162 μg

191.33 ± 11.98(****)

148.46 ± 9.74(****)

32.55 ± 4.13

5.07 ± 2.26

1.77 ± 0.59

4.78 ± 0.93

  NIST1650 a 18 μg

87.55 ± 7.706

10.94 ± 2.78

62.91 ± 4.77

0.36 ± 0.13

0.09 ± 0.09

 

  NIST1650 a 54 μg

72.238 ± 8.993

12.07 ± 5.46

50.56 ± 3.23

1.03 ± 0.98

0.10 ± 0.07

 

  NIST1650 a 162 μg

177.375 ± 16.756

120.54 ± 11.80

48.92 ± 5.75

1.23 ± 0.49

0.21 ± 0.15

 

Day 28

      

 Vehicle control

51.10 ± 3.89

0.10 ± 0.05

47.09 ± 3.89

0.16 ± 0.08

0.19 ± 0.08

3.55 ± 0.75

  CB 54 μg

75.63 ± 13.40

1.68 ± 0.75(*)

66.83 ± 12.12

0.04 ± 0.04

3.20 ± 0.77(*)

3.88 ± 0.55

  CAP 6 μg

50.20 ± 7.92

1.19 ± 0.84

42.50 ± 5.05

2.82 ± 2.64

1.03 ± 0.73

2.66 ± 0.88

  CAP 18 μg

60.23 ± 8.02

1.05 ± 0.68

46.83 ± 2.83

7.90 ± 5.98

1.43 ± 0.80

3.02 ± 0.65

  CAP 54 μg

48.85 ± 9.20

0.10 ± 0.07

39.18 ± 6.33

3.90 ± 2.76

2.42 ± 1.15(*)

3.25 ± 0.90

  JEP 6 μg

51.47 ± 11.08

0.13 ± 0.08

49.07 ± 10.53

0.02 ± 0.02

0.26 ± 0.09

2.00 ± 0.64

  JEP 18 μg

61.75 ± 7.01

0.27 ± 0.12

63.01 ± 4.84

0.23 ± 0.17

0.59 ± 0.25

2.94 ± 0.72

  JEP 54 μg

46.43 ± 8.56

0.68 ± 0.38(*)

40.18 ± 7.73

0.14 ± 0.07

0.87 ± 0.37(*)

4.56 ± 1.37

  NIST2975 18 μg

60.67 ± 7.71

0.27 ± 0.19

54.98 ± 7.61

0.09 ± 0.06

0.47 ± 0.11

4.87 ± 0.88

  NIST2975 54 μg

50.37 ± 6.07

0.21 ± 0.18

43.35 ± 6.67

0.08 ± 0.05

0.45 ± 0.27

6.27 ± 1.88

  NIST2975 162 μg

81.85 ± 8.40(*)

2.14 ± 0.92(**)

70.53 ± 7.43

0.30 ± 0.30

4.12 ± 1.93(**)

4.75 ± 0.43

  NIST1650a 18 μg

61.01 ± 3.13

0.44 ± 0.22

46.46 ± 2.98

0.11 ± 0.05

0.60 ± 0.12

 

  NIST1650 a 54 μg

58.26 ± 7.56

0.18 ± 0.07

45.83 ± 5.68

1.33 ± 0.78

1.27 ± 0.54

 

  NIST1650 a 162 μg

83.94 ± 10.64

1.86 ± 0.83

61.86 ± 6.29

0.28 ± 0.12

4.01 ± 1.25

 

Day 90

      

 Vehicle control

54.03 ± 5.14

0.45 ± 0.16

45.23 ± 4.39

0.98 ± 0.91

3.57 ± 3.39

3.80 ± 0.74

  CB 54 μg

86.93 ± 8.78(**)

2.07 ± 0.49(**)

73.33 ± 6.72

0.09 ± 0.09

4.70 ± 1.79

6.75 ± 1.58

  CAP 54 μg

62.75 ± 4.30

0.92 ± 0.33

56.68 ± 4.52

0.10 ± 0.10

1.30 ± 0.82

3.74 ± 0.39

  JEP 54 μg

50.90 ± 7.07

0.92 ± 0.47

42.69 ± 5.78

0.14 ± 0.07

1.74 ± 1.40

5.42 ± 1.51

  NIST2975 162 μg

48.42 ± 7.09

0.46 ± 0.18

45.11 ± 6.94

0.00 ± 0.00

0.38 ± 0.21

2.47 ± 0.44

  1. aNIST1650 data was included for comparison and obtained from a previously published study (Kyjovska et al. Mutagenesis 2015)
  2. P-value summary: (*) – (****) = p < 0.05 - p < 0.0001 increase compared to vehicle control, (x) – (xxxx) = p < 0.05 - p < 0.0001 increase compared to CB 54 μg, (¤) – (¤¤¤¤) = p < 0.05 - p < 0.0001 increase compared to NIST2975 of same dose, (‘) – (““) = p < 0.05 - p < 0.0001 increase compared to NIST1650 of same dose. Data are shown as Mean ± SEM (× 103)
  3. BAL broncho-alveloar lavage, CAP commercial airport particles, JEP jet engine particles, CB carbon black Printex 90
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Particle and Fibre Toxicology

ISSN: 1743-8977

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