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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Fig. 1

NP characterization. Representative images obtained by TEM of a Au-SC, b Au-PEG and c PLA-NP. d Quantification of NP size by TEM. e Z-average hydrodynamic diameter values of 6 μg/mL Au-SC and 20 μg/mL PLA-NP diluted in LUHMES and BrainSpheres culture media, analyzed by DLS after 0, 24 and 72 h of incubation. Results are expressed as mean (±SD). Each experimental group corresponds to the analysis of three independent experiments with three replicates. Statistical significance was analyzed by one-way ANOVA followed by Bonferroni’s multiple comparisons post-test (**p < 0.01, ***p < 0.001). Scale bar a 100 nm, b 25 nm and c 200 nm

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