Fig. 6From: Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug deliveryEffect of NP on expression of genes related to ROS regulation in BrainSpheres. Graphs showing the relative expression of SOD1, SOD2, NF2L2, GSTO1, NFR1 and CLEC7A after exposure to Au-SC (6 μg/mL), Au-PEG (20 μg/mL) and PLA-NP (20 μg/mL) for 72 h normalized to the expression of the genes in the untreated control spheroids. Data was collected from three independent experiments and represents fold changes (FC ± SEM, n = 3). One-way ANOVA with Bonferroni’s multiple comparisons post-test was used to analyze the statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001)Back to article page